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SRL
Identifiers
Aliases	SRL, entrez:6345, sarcalumenin, SAR
External IDs	OMIM: 604992; MGI: 2146620; HomoloGene: 45500; GeneCards: SRL; OMA:SRL - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 4,189,374 bp End 4,242,080 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 A1 Start 4,298,080 bp End 4,359,680 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh gastrocnemius muscle myocardium of left ventricle Skeletal muscle tissue of rectus abdominis apex of heart quadriceps femoris muscle vastus lateralis muscle cardiac muscle tissue of right atrium right auricle Skeletal muscle tissue of biceps brachii Top expressed in interventricular septum sternocleidomastoid muscle triceps brachii muscle temporal muscle vastus lateralis muscle extraocular muscle muscle of thigh medial head of gastrocnemius muscle ankle digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function GTP binding Cellular component sarcoplasmic reticulum sarcoplasmic reticulum lumen Biological process store-operated calcium entry response to muscle activity involved in regulation of muscle adaptation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6345 106393 Ensembl ENSG00000185739 ENSMUSG00000022519 UniProt Q86TD4 Q7TQ48 RefSeq (mRNA) NM_001098814 NM_001323667 NM_001323668 NM_175347 NM_001347162 NM_001361474 RefSeq (protein) NP_001092284 NP_001310596 NP_001310597 NP_001334091 NP_780556 NP_001348403 Location (UCSC) Chr 16: 4.19 – 4.24 Mb Chr 16: 4.3 – 4.36 Mb PubMed search
Wikidata
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Sarcalumenin is a protein that in humans is encoded by the SRL gene.

Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of striated muscle. Sarcalumenin is partially responsible for calcium buffering in the lumen of the sarcoplasmic reticulum and helps out calcium pump proteins. Additionally, sarcalumenin is necessary for keeping a normal sinus rhythm during both aerobic and anaerobic exercise activity. Sarcalumenin is a calcium-binding glycoprotein composed of 473 acidic amino acids with a molecular weight of 160 KDa. Together along with other luminal calcium buffer proteins, sarcalumenin plays an important role in regulation of calcium uptake and release during excitation-contraction coupling (ECC) in muscle fibers.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000185739 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022519 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Leberer E, Charuk JH, Green NM, MacLennan DH (August 1989). "Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum". Proceedings of the National Academy of Sciences of the United States of America. 86 (16): 6047–51. Bibcode:1989PNAS...86.6047L. doi:10.1073/pnas.86.16.6047. PMC 297772. PMID 2762314.
6. Lanfranchi G, Muraro T, Caldara F, Pacchioni B, Pallavicini A, Pandolfo D, Toppo S, Trevisan S, Scarso S, Valle G (January 1996). "Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization". Genome Research. 6 (1): 35–42. doi:10.1101/gr.6.1.35. PMID 8681137.
7. ^ Jiao Q, Bai Y, Akaike T, Takeshima H, Ishikawa Y, Minamisawa S (August 2009). "Sarcalumenin is essential for maintaining cardiac function during endurance exercise training". American Journal of Physiology. Heart and Circulatory Physiology. 297 (2): H576-82. doi:10.1152/ajpheart.00946.2008. PMC 2724216. PMID 19502553.
8. Yoshida M, Minamisawa S, Shimura M, Komazaki S, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Saeki Y, Ishikawa Y, Yanagisawa T, Takeshima H (February 2005). "Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice". The Journal of Biological Chemistry. 280 (5): 3500–6. doi:10.1074/jbc.M406618200. PMID 15569689.

External links

• sarcalumenin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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