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Small nucleolar RNA SNORA68
Predicted secondary structure and sequence conservation of SNORA68
Identifiers
Symbol	SNORA68
Alt. Symbols	U68
Rfam	RF00263
Other data
RNA type	Gene; snRNA; snoRNA; H/ACA-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000594
PDB structures	PDBe

In molecular biology, Small nucleolar RNA SNORA68 (also known as U68) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

ACA68 was originally cloned from HeLa cells and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA68 is predicted to guide the pseudouridylation of U4393 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

References

1. Ganot P, Caizergues-Ferrer M, Kiss T (April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development. 11 (7): 941–56. doi:10.1101/gad.11.7.941. PMID 9106664.

External links

• Page for Small nucleolar RNA SNORA68 at Rfam
• Entry for U68 at snoRNABase

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