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Small nucleolar RNA SNORA74
Predicted secondary structure and sequence conservation of SNORA74
Identifiers
Symbol	SNORA74
Alt. Symbols	U19
Rfam	RF00090
Other data
RNA type	Gene; snRNA; snoRNA; H/ACA-box
Domain(s)	Eukaryota
GO	GO:0006396 GO:0005730
SO	SO:0000594
PDB structures	PDBe

In molecular biology, Small nucleolar RNA SNORA74 (U19) belongs to the H/ACA class of snoRNAs. snoRNAs bind a number of proteins (including dyskerin, Gar1p and Nop10p in the case of the H/ACA class) to form snoRNP complexes. This class is thought to guide the sites of modification of uridines to pseudouridines by forming direct base pairing interactions with substrate RNAs. Targets may include ribosomal and spliceosomal RNAs but the exact functions of many snoRNAs, including U19, are not confirmed. Co-precipitation of U19 snoRNA with RNase MRP RNA suggests that U19 may be involved in pre-rRNA processing.

References

1. Ganot P, Caizergues-Ferrer M, Kiss T (April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development. 11 (7): 941–56. doi:10.1101/gad.11.7.941. PMID 9106664.
2. Kiss T, Bortolin ML, Filipowicz W (April 1996). "Characterization of the intron-encoded U19 RNA, a new mammalian small nucleolar RNA that is not associated with fibrillarin". Molecular and Cellular Biology. 16 (4): 1391–400. doi:10.1128/MCB.16.4.1391. PMC 231123. PMID 8657112.
3. Bortolin ML, Kiss T (April 1998). "Human U19 intron-encoded snoRNA is processed from a long primary transcript that possesses little potential for protein coding". RNA. 4 (4): 445–54. PMC 1369630. PMID 9630250.

External links

• Page for Small nucleolar RNA SNORA74 at Rfam

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