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Sutezolid

Clinical data
Other names	PNU-100480, PF-02341272
Identifiers
IUPAC name N-methyl]acetamide
CAS Number	168828-58-8
PubChem CID	465951
DrugBank	DB11905
ChemSpider	409595
UNII	3A71182L8P
KEGG	D10167
ChEMBL	ChEMBL288149
CompTox Dashboard (EPA)	DTXSID20168611
ECHA InfoCard	100.237.103
Chemical and physical data
Formula	C16H20FN3O3S
Molar mass	353.41 g·mol
3D model (JSmol)	Interactive image
SMILES CC(=O)NC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCSCC3)F
InChI InChI=InChI=1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1 Key:FNDDDNOJWPQCBZ-ZDUSSCGKSA-N

Sutezolid is an investigational new drug that is being evaluated for the treatment of extensively drug-resistant tuberculosis. It differs from linezolid by replacement of the morpholine oxygen with a sulfur atom. Like linezolid, sutezolid is a bacterial protein synthesis inhibitor. In preclinical studies, sutezolid demonstrated superior antituberculosis activity compared to linezolid.

References

1. "Sutezolid - Global Alliance for TB Drug Development/Sequella". AdisInsight. Springer Nature Switzerland AG.
2. Chen RH, Burke A, Cho JG, Alffenaar JW, Davies Forsman L (June 2024). "New Oxazolidinones for Tuberculosis: Are Novel Treatments on the Horizon?". Pharmaceutics. 16 (6): 818. doi:10.3390/pharmaceutics16060818. PMC 11207443. PMID 38931939.

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