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Tabun

Names
IUPAC name (RS)-Ethyl N,N-Dimethylphosphoramidocyanidate
Other names GA; Ethyl dimethylphosphoramidocyanidate; Dimethylaminoethoxy-cyanophosphine oxide; Dimethylamidoethoxyphosphoryl cyanide; Ethyl dimethylaminocyanophosphonate; Ethyl ester of dimethylphosphoroamidocyanidic acid; Ethyl phosphorodimethylamidocyanidate; Cyanodimethylaminoethoxyphosphine oxide; Dimethylaminoethodycyanophosphine oxide; EA-1205; TL-1578
Identifiers
CAS Number	77-81-6
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1097650
ChemSpider	6254
PubChem CID	6500
UNII	S45M750QSH
CompTox Dashboard (EPA)	DTXSID80861631
InChI InChI=1S/C5H11N2O2P/c1-4-9-10(8,5-6)7(2)3/h4H2,1-3H3Key: PJVJTCIRVMBVIA-UHFFFAOYSA-N InChI=1/C5H11N2O2P/c1-4-9-10(8,5-6)7(2)3/h4H2,1-3H3Key: PJVJTCIRVMBVIA-UHFFFAOYAG
SMILES N#CP(=O)(OCC)N(C)C
Properties
Chemical formula	C5H11N2O2P
Molar mass	162.129 g·mol
Appearance	Colorless to brown liquid
Density	1.0887 g/cm at 25 °C 1.102 g/cm at 20 °C
Melting point	−50 °C (−58 °F; 223 K)
Boiling point	247.5 °C (477.5 °F; 520.6 K)
Solubility in water	9.8 g/100 g at 25 °C 7.2 g/100 g at 20 °C
Vapor pressure	0.07 mmHg (9 Pa)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	Highly toxic. Fires involving this chemical may result in the formation of hydrogen cyanide
NFPA 704 (fire diamond)	4 2 1
Flash point	78 °C (172 °F; 351 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). N verify (what is  ?) Infobox references

Tabun (military designation GA) is an extremely toxic compound of the organophosphate family. It is not present in nature. At room temperature, the pure compound is a clear and viscous liquid. However, impurities imparted during its manufacture are almost always present, turning it into a yellow or brown liquid. Exposed to environs, it slowly volatizes into the atmosphere, with the vapor having a slight fruity or almond-like odor. As the compound has a much higher molecular mass (162 g/mol) compared to air, Tabun gas tends to accumulate in low-lying areas.

It is a potent inhibitor of acetylcholinesterase, a key enzyme within the human body as well as in other animals. Acetylcholinesterase is responsible for breaking down acetylcholine, a neurotransmitter released into the synaptic cleft by motor neurons. The presence of acetylcholine within the cleft signals the post-synaptic (downstream) motor neuron to contract the neuron's associated muscle fibers, and vice versa. By irreversibly phosphorylating the enzyme, Tabun accomplishes a constant and involuntary contraction of the affected muscles, as the acetylcholine is not recycled and continues to build up within the cleft. Death of the organism ensues when respiratory muscles, such as the diaphragm and intercostals, become exhausted and paralyzed from constant contraction, leading to loss of respiratory functions.

The production and storage of Tabun has been strictly regulated under the Chemical Weapons Convention and its implementing agency OPCW since 1997. As a Schedule 1 Toxic Chemical, the synthesis of more than 100 grams of the substance per year must be declared to the organization, and no signing nation can possess more than 1 ton of the chemical. Modern usage of Tabun is limited to research purposes in minute amounts.

Chemistry and Synthesis

Reactions

Tabun can be deactivated chemically using common oxidizing agents such as sodium hypochlorite.

Historic synthesis

Tabun was made on an industrial scale by Germany during World War II, based on a process developed by Gerhard Schrader. In the chemical agent factory in Dyhernfurth an der Oder, code-named "Hochwerk", at least 12,000 metric tons of this agent were manufactured between 1942 and 1945. The manufacturing process consisted of two steps (see below); after the reactions, the mixture (consisting of ~75% solvent, ~25% desired product, plus insoluble salts and reactants) was filtered and vacuum-distilled. This yielded a technical product consisting either of 95% or 80% tabun (then known as Tabun A or B, respectively, the second a product later in the war).

Effects of exposure

The symptoms of exposure include: nervousness/restlessness, miosis (contraction of the pupil), rhinorrhea (runny nose), excessive salivation, dyspnea (difficulty in breathing due to bronchoconstriction/secretions), sweating, bradycardia (slow heartbeat), loss of consciousness, convulsions, flaccid paralysis, loss of bladder and bowel control, apnea (breathing stopped) and lung blisters. The symptoms of exposure are similar to those created by all nerve agents. Tabun is toxic even in minute doses. The number and severity of symptoms which appear vary according to the amount of the agent absorbed and rate of entry of it into the body. Very small skin dosages sometimes cause local sweating and tremors accompanied with characteristically constricted pupils with few other effects. Tabun is about half as toxic as sarin by inhalation, but in very low concentrations it is more irritating to the eyes than sarin. Tabun also breaks down slowly, which after repeated exposure can lead to build up in the body.

The effects of tabun appear slowly when tabun is absorbed through the skin rather than inhaled. A victim may absorb a lethal dose quickly, although death may be delayed for one to two hours. A person's clothing can release the toxic chemical for up to 30 minutes after exposure. Inhaled lethal dosages kill in one to ten minutes, and liquid absorbed through the eyes kills almost as quickly. However, people who experience mild to moderate exposure to tabun can recover completely, if treated almost as soon as exposure occurs. The median lethal dose (LD₅₀) for tabun is about 400 mg-min/m.

The lethal dose for a man is about .01 mg/kg. The median lethal dose for respiration is 400 mg-minute/m3 for humans. Respiratory lethal doses can kill anytime from 1-10 minutes. When the liquid enters the eye, it also can kill just as quickly. When absorbed via the skin, death may occur in 1-2 minutes, or it can take up to 2 hours.

Treatment for suspected tabun poisoning is often three injections of a nerve agent antidote, such as atropine. Pralidoxime chloride (2-PAM Cl) also works as an antidote; however, it must be administered within minutes to a few hours following exposure to be effective.

History

Research into ethyl dialkylaminocyanophosphonate began in the late 19th century, In 1898, Adolph Schall, a graduate student at the University of Rostock under professor August Michaelis, synthesised the diethylamino analog of tabun, as part of his PhD thesis Über die Einwirkung von Phosphoroxybromid auf secundäre aliphatische Amine. However, Schall incorrectly identified the structure of the substance as an imidoether, and Michaelis corrected him in a 1903 article in Liebigs Annalen, Über die organischen Verbindungen des Phosphors mit dem Stickstoff. The high toxicity of the substance (as well as the high toxicity of its precursors, diethylamidophosphoric dichloride and dimethylamidophosphoric dichloride) wasn't noticed at the time, most likely due to the low yield of the synthetic reactions used.

Tabun became the first nerve agent known after a property of this chemical was discovered by pure accident in late December 1936 by German researcher Gerhard Schrader. Schrader was experimenting with a class of compounds called organophosphates, which kill insects by interrupting their nervous systems, to create a more effective insecticide for IG Farben, a German chemical and pharmaceutical industry conglomerate, at Elberfeld. The substance he discovered, as well as being a potent insecticide, was enormously toxic to humans; hence, it was named tabun, a tongue-in-cheek codename to indicate that the substance was 'taboo' (German: tabu) for its intended purpose.

During World War II, as part of the Grün 3 program, a plant for the manufacture of tabun was established at Dyhernfurth (now Brzeg Dolny, Poland), in 1939. Run by Anorgana GmbH, the plant began production of the substance in 1942. The reason for the delay was the extreme precautions used by the plant. Intermediate products of tabun were corrosive, and had to be contained in quartz or silver-lined vessels. Tabun itself was also highly toxic, and final reactions were conducted behind double glass walls. Large scale manufacturing of the agent resulted in problems with tabun's degradation over time, and only around 12,500 tons of material were manufactured before the plant was seized by the Soviet Army. The plant initially produced shells and aerial bombs using a 95:5 mix of tabun and chlorobenzene, designated "Variant A". In the latter half of the war, the plant switched to "Variant B", an 80:20 mix of tabun and chlorobenzene designed for easier dispersion. The Soviets dismantled the plant and shipped it to Russia.

During the Nuremberg Trials, Albert Speer, Minister of Armaments and War Production for the Third Reich, testified that he had planned to kill Adolf Hitler in early 1945 by introducing tabun into the Führerbunker ventilation shaft. He said his efforts were frustrated by the impracticality of tabun and his lack of ready access to a replacement nerve agent, and also by the unexpected construction of a tall chimney that put the air intake out of reach.

The US once considered repurposing captured German stocks of tabun (GA) prior to production of Sarin (GB). Like the other Allied governments, the Soviets soon abandoned tabun (GA) for Sarin (GB) and Soman (GD). Large quantities of the German-manufactured agent were dumped into the sea to neutralize the substance.

Since GA is much easier to produce than the other G-series weapons and the process is comparatively widely understood, countries that develop a nerve agent capability but lack advanced industrial facilities often start by producing GA.

During the Iran–Iraq War of 1980 to 1988, Iraq employed quantities of chemical weapons against Iranian ground forces. Although the most commonly used agents were mustard gas and sarin, tabun and cyclosarin were also used.

Tabun was also used in the 1988 Halabja chemical attack.

Producing or stockpiling tabun was banned by the 1993 Chemical Weapons Convention. The worldwide stockpiles declared under the convention were 2 tonnes, and as of December 2015 these stockpiles had been destroyed.

See also

• Cyclosarin (GF)
• Deseret Chemical Depot – where the remaining US stockpile was destroyed
• Operation Sandcastle – dumping of World War II German tabun bombs by the UK in 1955–1956
• Francis E. Dec - Schizophrenic and World War II veteran, spoke about the "Tabin Needle" in rants

References

1. "CBRNE - Nerve Agents, G-series - Tabun, Sarin, Soman: Practice Essentials, Pathophysiology, Epidemiology". Medscape. 2021-10-02.
2. ^ "CBRNE - Nerve Agents, G-series - Tabun, Sarin, Soman: Practice Essentials, Pathophysiology, Epidemiology". CBRNE. Pathophysiology. 2021-10-02 – via Medscape.
3. "NRT CBRN Tabun 2022 07 26.pdf" (PDF). NRT.org.
4. ^ "Tabun (GA): Nerve Agent | NIOSH | CDC". www.cdc.gov. 2024-04-26. Retrieved 2024-07-26.
5. PubChem. "Tabun". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-07-26.
6. "Tabun - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024-07-26.
7. "Schedule 1". OPCW. Retrieved 2024-07-26.
8. "Chemical Weapons Convention - CWC_en.pdf". OPCW. p. 4. Retrieved 2024-07-26.
9. "Chemical Weapons Convention - CWC_en.pdf". OPCW. p. 124. Retrieved 2024-07-26.
10. "Sodium Hypochlorite - Medical Countermeasures Database - CHEMM". chemm.hhs.gov. Retrieved 2023-11-25.
11. ^ Lohs, K. (1967). "3. Gifte, deren Wirkung sich hauptsächlich auf das Nervensystem bzw. auf lebenswichtige Enzyme erstreckt ". Synthetische Gifte: Zur Chemie, Toxikologie und zu Problemen ihrer völkerrechtswidrigen Anwendung durch imperialistische Armeen [Synthetic poisons: On the chemistry, toxicology and problems of their illegal use by imperialist armies] (PDF) (in German) (überarb. u. erg.  ed.). Berlin : Militärverlag der Deutschen Demokratischen Republik (Military Publisher's of the German Democratic Republic). Retrieved 31 March 2024. The translations of chapter and book title here were editor-generated.
12. ^ "Nerve Agent: GA". Cbwinfo.com. Archived from the original on 2011-09-27. Retrieved 2008-11-06.
13. ^ "Chemical Warfare Weapons Fact Sheets — Tabun — GA Nerve Agent". Usmilitary.about.com. Archived from the original on 2016-03-03. Retrieved 2008-11-06.
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15. ^ Facts About Tabun, National Terror Alert Response System
16. "ATSDR — MMG: Nerve Agents: Tabun (GA); Sarin (GB); Soman (GD); and VX". Atsdr.cdc.gov. Archived from the original on April 23, 2003. Retrieved 2008-11-06.
17. PubChem. "Tabun". pubchem.ncbi.nlm.nih.gov. Retrieved 2023-03-02.
18. Emergency Response Safety and Health Database. TABUN (GA): Nerve Agent. National Institute for Occupational Safety and Health. Accessed April 30, 2009.
19. Petroianu, Georg (2014). "Pharmacists Adolf Schall and Ernst Ratzlaff and the synthesis of tabun-like compounds: a brief history". Die Pharmazie. 69 (October 2014): 780–784. doi:10.1691/ph.2014.4028. PMID 25985570.
20. Chemical Warfare Weapons Fact Sheets Archived 2016-03-03 at the Wayback Machine, about.com
21. Chemical Weapons: Nerve Agents, University of Washington
22. ^ "A Short History of the Development of Nerve Gases". Noblis.org. Archived from the original on 2011-04-15. Retrieved 2008-11-06.
23. Everts, Sarah (17 October 2016). "The Nazi origins of deadly nerve gases". No. 94, 41. Chemical & Engingeering News. Retrieved 13 July 2024.
24. ^ Speer 1970, pp. 430–31.
25. Kirby, Reid (2006). "America's Fifteen-Year Struggle for Modern Chemical Weapons" (PDF). Army Chemical Review (Jan.–Jun): 42–44. Archived from the original (PDF) on 2017-02-11. Retrieved 31 March 2024.
26. ABC News Staff (April 7, 2003). "Facts About the Nerve Agent Tabun". ABCNews.go.com ABC News. Retrieved 31 March 2024.
27. "1988: Thousands die in Halabja gas attack". March 16, 1988 – via news.bbc.co.uk.
28. Organisation for the Prohibition of Chemical Weapons (30 November 2016). "Annex 3". Report of the OPCW on the Implementation of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction in 2015 (Report). p. 42. Retrieved 8 March 2017.

Bibliography

• Speer, Albert (1970), Inside the Third Reich, translated by Richard Winston; Clara Winston, New York and Toronto: Macmillan, ISBN 978-0-297-00015-0, LCCN 70119132. Republished in paperback in 1997 by Simon & Schuster, ISBN 978-0-684-82949-4

  (Original German edition: Speer, Albert (1969), Erinnerungen [Reminiscences], Berlin and Frankfurt am Main: Propyläen/Ullstein Verlag, OCLC 639475)

Further reading

• United States Senate, 103d Congress, 2d Session. (May 25, 1994). Material Safety Data Sheet—Lethal Nerve Agent Tabun (GA). Retrieved Nov. 6, 2004.
• United States Central Intelligence Agency (Jul. 15, 1996) Stability of Iraq's Chemical Weapon Stockpile Archived 2011-04-28 at the Wayback Machine
• Norris, John (1997). NBC: Nuclear, Biological and Chemical Warfare on the Modern Battlefield. Brassey's UK. p. 20. ISBN 1-85753-182-5.

• Acetylcholinesterase inhibitors
• G-series nerve agents
• Nitriles
• Ethyl esters
• Organophosphates
• German inventions of the Nazi period
• German chemical weapons program