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Terizidone

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Chemical compound Pharmaceutical compound
Terizidone
Clinical data
Other names4-phenyl}methylidene)amino]-1,2-oxazolidin-3-one
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • C
ATC code
Identifiers
IUPAC name
  • 4,4'-{1,4-Phenylenebis}bis(1,2-oxazolidin-3-one)
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.042.882 Edit this at Wikidata
Chemical and physical data
FormulaC14H14N4O4
Molar mass302.290 g·mol
3D model (JSmol)
SMILES
  • O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2
InChI
  • InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+
  • Key:ODKYYBOHSVLGNU-IAGONARPSA-N
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Terizidone is a drug used in the treatment of tuberculosis. Terizidone is mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivate of cycloserine and it is bacteriostatic.

References

  1. Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, Massaglia GM (1991). "". Minerva Medica. 82 (7–8): 477–81. PMID 1922892.
  2. Rossiter D (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.
Antimycobacterials, including tuberculosis treatment and leprostatic agents (J04)
Nucleic acid inhibitor
Rifamycins/
RNA polymerase inhibitor
Antifolates/DSI
ASA
Topoisomerase inhibitors/
quinolones
Protein synthesis inhibitor
Aminoglycosides
Oxazolidone
Polypeptide antibiotics
Cell envelope antibiotic
Peptidoglycan layer
Arabinogalactan layer
Mycolic acid layer
Other/unknown
Combinations
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