Misplaced Pages

Herpes simplex virus protein vmw65

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.
(Redirected from Vp16)
Alpha trans-inducing protein (Alpha-TIF)
Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16.
Identifiers
SymbolAlpha_TIF
PfamPF02232
InterProIPR003174
SMARTSM00814
SCOP216vp / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB16vp​

Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor) is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.

VP16 is a strong transactivator and is often used in Y2H systems as the activation domain of the system.

References

  1. Liu Y, Gong W, Huang CC, Herr W, Cheng X (July 1999). "Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16". Genes Dev. 13 (13): 1692–703. doi:10.1101/gad.13.13.1692. PMC 316849. PMID 10398682.
  2. Entry for Vmw65 on Cure hunter
  3. O'Reilly D, Hanscombe O, O'Hare P (May 1997). "A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II". EMBO J. 16 (9): 2420–30. doi:10.1093/emboj/16.9.2420. PMC 1169842. PMID 9171355.
  4. Wysocka J, Herr W (June 2003). "The herpes simplex virus VP16-induced complex: the makings of a regulatory switch". Trends Biochem. Sci. 28 (6): 294–304. doi:10.1016/S0968-0004(03)00088-4. PMID 12826401.
  5. Hirai, Hiroyuki; Tani, Tetsuya; Kikyo, Nobuaki (2010). "Structure and functions of powerful transactivators: VP16, MyoD and FoxA". The International Journal of Developmental Biology. 54 (11–12): 1589–1596. doi:10.1387/ijdb.103194hh. PMC 3419751. PMID 21404180.
  6. Stynen, B.; Tournu, H.; Tavernier, J.; Van Dijck, P. (11 June 2012). "Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System". Microbiology and Molecular Biology Reviews. 76 (2): 331–382. doi:10.1128/MMBR.05021-11. PMC 3372256. PMID 22688816.
Viral proteins (early and late)
DNA
linear ds-DNA
(Duplodnaviria,
Varidnaviria)
Herpes simplex
VSPs:
capsid:
VNPs:
Vaccinia
VNPs:
Adenoviridae
VNPs:
circular ds-DNA
(Duplodnaviria,
Varidnaviria?)
Epstein–Barr
VSPs:
VNPs:
ncRNA:
Baculoviridae
VNPs:
other
(Riboviria,
Monodnaviria)
Polyomaviridae
(SV40, MPyV, MCPyV, HaPyV)
(non-enveloped circular ds-DNA)
VSPs:
capsid:
VNPs:
oncoprotein:
Hepatitis B
(circular partially ds-DNA)
VSPs:
  • HBsAg
  • HBcAg
    • VNPs:
    RNA
    ds-RNA
    (Riboviria)
    Rotavirus
    (Duplornaviricota)
    VNPs:
    Rhinov., Polio, Hep A,
    etc. (Pisuviricota)
    VNPs:
    ss-RNA
    positive-sense
    (Riboviria)
    Hepatitis C
    (Kitrinoviricota)
    VSPs:
    VNPs:
    SARS-CoV-2
    (Pisuviricota)
    VSPs:
    VNPs:
    ss-RNA
    negative-sense
    (Negarnaviricota)
    Influenza virus
    VSPs:
    capsid:
    glycoprotein:
    VNPs:
    Parainfluenza
    VSPs:
    glycoprotein:
    Mumps
    VSPs:
    glycoprotein:
    Measles
    VSPs:
    glycoprotein:
    RSV
    VSPs:
    glycoprotein:
    Zaire ebolavirus
    VSPs:
    capsid:
    Indiana vesiculovirus
    VSPs:
    capsid:
    RT
    Structure and genome of HIV
    VSPs:
    VRAPs:
    Multiple
    Fusion protein
    oncoprotein:
  • Gag-onc fusion protein


    • Stub icon

    This virus-related article is a stub. You can help Misplaced Pages by expanding it.

    Categories: