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{{Short description|Broad-spectrum herbicide}}
{{Distinguish|Glyphosate}} {{Distinguish|Glyphosate}}
{{chembox {{chembox
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| ImageFile1 = Glufosinate zwitterion 3D ball.png | ImageFile1 = Glufosinate zwitterion 3D ball.png
| ImageAlt1 = Ball-and-stick model of the glufosinate zwitterion | ImageAlt1 = Ball-and-stick model of the glufosinate zwitterion
| IUPACName = (''RS'')-2-Amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid | PIN = 2-Amino-4-butanoic acid
| OtherNames = Phosphinothricin | OtherNames = Phosphinothricin
|Section1 = {{Chembox Identifiers |Section1 = {{Chembox Identifiers
Line 15: Line 16:
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C05042 | KEGG = C05042
| InChI = 1/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)
| InChIKey = IAJOBQBIJHVGMQ-UHFFFAOYAF
| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 450298 | ChEMBL = 450298
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| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| CASNo = 51276-47-2 | CASNo = 51276-47-2
| CASNo1_Ref = {{cascite|changed|CAS}}
| CASNo1 = 77182-82-2
| CASNo1_Comment = (monoammonium salt)
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = C8W4FP6BTY
| EINECS = 257-102-5 | EINECS = 257-102-5
| PubChem = 4794 | PubChem = 4794
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| ChEBI = 52136 | ChEBI = 52136
| SMILES = O=P(O)(CCC(C(=O)O)N)C | SMILES = O=P(O)(CCC(C(=O)O)N)C
}} }}
|Section2 = {{Chembox Properties |Section2 = {{Chembox Properties
| C=5 | H=12 | N=1 | O=4 | P=1 | C=5 | H=12 | N=1 | O=4 | P=1
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}} }}


'''Glufosinate''' (also known as '''phosphinothricin''' and often sold as an ]) is a naturally occurring broad-spectrum systemic ] produced by several species of '']'' soil bacteria. Plants also metabolise ], another naturally occurring herbicide, directly into glufosinate.<ref>{{cite journal | doi = 10.1128/AEM.70.12.7093-7102.2004 | volume=70 | title=Biosynthetic Gene Cluster of the Herbicide Phosphinothricin Tripeptide from Streptomyces viridochromogenes Tu494 | journal=Applied and Environmental Microbiology | pages=7093–7102| pmc=535184 }}</ref> The compound irreversibly inhibits ], an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it ], ] and herbicidal properties. Application of glufosinate to plants leads to reduced ] and elevated ] levels in tissues, halting ], resulting in plant death.<ref name=PAN>{{cite web|url = http://www.pan-uk.org/pestnews/Actives/glufosin.htm |title = Glufosinate ammonium fact sheet |date = December 1998 |accessdate = March 2015|publisher = Pesticides News No.42 |last = Topsy Jewell for Friends of the Earth}}</ref> '''Glufosinate''' (also known as '''phosphinothricin''' and often sold as an ]) is a naturally occurring broad-spectrum ] produced by several species of '']'' soil bacteria. Glufosinate is a non-selective, contact herbicide, with some systemic action.<ref>{{cite web |url=http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/372.htm |title=glufosinate-ammonium |website=PPDB: Pesticide Properties DataBase |access-date= }}</ref> Plants may also metabolize ] and ], other naturally occurring herbicides, directly into glufosinate.<ref>{{cite journal | doi = 10.1128/AEM.70.12.7093-7102.2004 | pmid=15574905 | volume=70 | issue=12 | title=Biosynthetic Gene Cluster of the Herbicide Phosphinothricin Tripeptide from Streptomyces viridochromogenes Tu494 | journal=Applied and Environmental Microbiology | pages=7093–7102| pmc=535184 | year=2004 | last1=Schwartz | first1=D. | last2=Berger | first2=S. | last3=Heinzelmann | first3=E. | last4=Muschko | first4=K. | last5=Welzel | first5=K. | last6=Wohlleben | first6=W. | bibcode=2004ApEnM..70.7093S }}</ref> The compound irreversibly inhibits ], an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it ], ] and herbicidal properties. Application of glufosinate to plants leads to reduced ] and elevated ] levels in tissues, halting ] and resulting in plant death.<ref name=PAN>{{cite web |url = http://www.pan-uk.org/pestnews/Actives/glufosin.htm |title = Glufosinate ammonium fact sheet |date = December 1998 |access-date = |publisher = Pesticides News No.42 |last = Topsy Jewell for Friends of the Earth |archive-url = https://web.archive.org/web/20150701084024/http://www.pan-uk.org/pestnews/Actives/glufosin.htm |archive-date = 2015-07-01 |url-status = dead }}</ref>


==Discovery== ==Discovery==
In the 1960s and early 1970s, scientists at ] and at the ] independently discovered that species of '']'' bacteria produce a tripeptide they called ] that inhibits bacteria; it consists of two ] residues and a unique ] that is an analog of ] that they named "phosphinothricin".<ref name=Donn/>{{rp|90}} They determined that phosphinothricin irreversibly inhibits ].<ref name=Donn/>{{rp|90}} Phosphinothricin was first synthesized by scientists at ] in the 1970s as a ] mixture; this racemic mixture is called glufosinate and is the commercially relevant version of the chemical.<ref name=Donn>Donn, G and Köcher, H. Inhibitors of Glutamine Synthetase. Chapter 4 in Herbicide Classes in Development: Mode of Action, Targets, Genetic Engineering, Chemistry. Eds Peter Böger, Ko Wakabayashi, Kenji Hirai. Springer Science & Business Media, 2012 {{ISBN|9783642594168}}</ref>{{rp|91–92}} In the 1960s and early 1970s, scientists at ] and at the ] independently discovered that species of '']'' bacteria produce a tripeptide they called ] that inhibits bacteria; it consists of two ] residues and a unique ] that is an analog of ] that they named "phosphinothricin".<ref name=Donn/>{{rp|90}} They determined that phosphinothricin irreversibly inhibits ].<ref name=Donn/>{{rp|90}} Phosphinothricin was first synthesized by scientists at ] in the 1970s as a ] mixture; this racemic mixture is called glufosinate and is the commercially relevant version of the chemical.<ref name=Donn>Donn, G and Köcher, H. Inhibitors of Glutamine Synthetase. Chapter 4 in Herbicide Classes in Development: Mode of Action, Targets, Genetic Engineering, Chemistry. Eds Peter Böger, Ko Wakabayashi, Kenji Hirai. Springer Science & Business Media, 2012 {{ISBN|9783642594168}}</ref>{{rp|91–92}}


In the late 1980s scientists discovered enzymes in these ''Streptomyces'' species that selectively inactivate free phosphinothricin; the gene encoding the enzyme that was isolated from '']'' was called the "bialaphos resistance" or "bar" gene, and the gene encoding the enzyme in '']'' was called "]" or "pat".<ref name=Donn/>{{rp|98}} The two genes and their proteins have 80% homology on the DNA level and 86% amino acid homology, and are each 158 amino acids long.<ref name=Donn/>{{rp|98}} In the late 1980s scientists discovered enzymes in these ''Streptomyces'' species that selectively inactivate free phosphinothricin; the gene encoding the enzyme that was isolated from '']'' was called the "bialaphos resistance" or "bar" gene, and the gene encoding the enzyme in '']'' was called "]" or "pat".<ref name=Donn/>{{rp|98}} The two genes and their proteins have 80% homology on the DNA level and 86% amino acid homology, and are each 158 amino acids long.<ref name=Donn/>{{rp|98}}


==Use== ==Use==
]
⚫ Glufosinate is a broad-spectrum herbicide that is used to control important weeds such as ], hemp sesbania (]), Pennsylvania smartweed (]) and ] similar to ]. It is applied to young plants during early development for full effectiveness.<ref name=PAN/> It is sold in formulations under brands including Basta, Rely, Finale, Challenge and Liberty.<ref name=PAN/>


⚫ Glufosinate is a broad-spectrum herbicide that is used to control important weeds such as ], hemp sesbania (]), Pennsylvania smartweed (]) and ] similar to ]. It is applied to young plants during early development for full effectiveness.<ref name=PAN/> It is sold in formulations under brands including Basta, Rely, Finale, Challenge and Liberty.<ref name=PAN/>
Glufosinate is typically used in three situations as an herbicide: Glufosinate is typically used in three situations as an herbicide:
*directed sprays for weed control, including in ] *directed sprays for weed control, including in ]
*use as a ] to facilitate harvesting<ref name=moneuro>{{cite web | url=http://www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf | title=The agronomic benefits of glyphosate in Europe | publisher=] Europe SA | date=February 2010 | deadurl=yes | archiveurl=https://web.archive.org/web/20120117143642/http://www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf | archivedate=2012-01-17 | df= }}</ref> *use as a ] to facilitate harvesting<ref name=moneuro>{{cite web | url=http://www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf | title=The agronomic benefits of glyphosate in Europe | publisher=] Europe SA | date=February 2010 | url-status=dead | archive-url=https://web.archive.org/web/20120117143642/http://www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf | archive-date=2012-01-17 }}</ref>


]
Glufosinate also has shown to provide some protection against various plant diseases, as it also acts to kill fungi and bacteria on contact.<ref name=Duke>Duke, SO. Biotechnology: Herbicide Resistant Crops. In Encyclopedia of Agriculture and Food Systems, 2nd edition. Ed. Neal K. Van Alfen. Elsevier, 2014. {{ISBN|9780080931395}}. </ref> Glufosinate also has shown to provide some protection against various plant diseases, as it also acts to kill fungi and bacteria on contact.<ref name=Duke>Duke, SO. Biotechnology: Herbicide Resistant Crops. In Encyclopedia of Agriculture and Food Systems, 2nd edition. Ed. Neal K. Van Alfen. Elsevier, 2014. {{ISBN|9780080931395}}. </ref>


Line 69: Line 73:
Phosphinothricin is a ] ] that binds to the ] site. Glufosinate-treated plants die due to a buildup of ] in the ] lumen, leading to the uncoupling of ].<ref name=Duke/> The uncoupling of photophosphorylation causes the production of ], ], and membrane destruction.<ref>, HRAC and WSSA</ref> Phosphinothricin is a ] ] that binds to the ] site. Glufosinate-treated plants die due to a buildup of ] in the ] lumen, leading to the uncoupling of ].<ref name=Duke/> The uncoupling of photophosphorylation causes the production of ], ], and membrane destruction.<ref>, HRAC and WSSA</ref>


Elevated levels of ammonia are detectable within one hour after application of Phosphinothricin.<ref name=PAN/> Elevated levels of ammonia are detectable within one hour after application of phosphinothricin.<ref name=PAN/>


==Toxicity== ==Toxicity==


===Exposure to humans in foods=== ===Exposure to humans in foods===
As glufosinate is often used as a pre-harvest ], residues can also be found in foods that humans ingest. Such foods include potatoes, peas, beans, corn, wheat, and barley. In addition, the chemical can be passed to humans through animals who are fed contaminated straw. Flour processed from wheat grain that contained traces of glufosinate was found to retain 10-100% of the chemicals' residues.<ref name=monograph>{{cite web|last1=Watts|first1=Meriel|title=Glufosinate Ammonium Monograph|url=http://www.pananz.net/wp-content/uploads/2013/04/Glufosinate-monograph-12-Dec-2008.pdf|publisher=] Asia and the Pacific|accessdate=20 April 2015}}</ref> As glufosinate is often used as a pre-harvest ], it can be found in foods that humans ingest. Such foods include potatoes, peas, beans, corn, wheat, and barley. In addition, the chemical can be passed to humans through animals who are fed contaminated straw. Flour processed from wheat grain that contained traces of glufosinate was found to retain 10-100% of the chemicals' residues.<ref name=monograph>{{cite web|last1=Watts|first1=Meriel|title=Glufosinate Ammonium Monograph|url=http://www.pananz.net/wp-content/uploads/2013/04/Glufosinate-monograph-12-Dec-2008.pdf|publisher=] Asia and the Pacific|access-date=20 April 2015}}</ref>


The herbicide is also persistent; it has been found to be prevalent in spinach, radishes, wheat and carrots that were planted 120 days after the treatment of the herbicide.<ref name=PAN/> Its persistent nature can also be observed by its ] which varies from 3 to 70 days depending on the soil type and organic matter content.<ref name=PAN/> Residues can remain in frozen food for up to two years and the chemical is not easily destroyed by cooking the food item in boiling water.<ref name=monograph /> The EPA classifies the chemical as 'persistent' and 'mobile' based on its lack of degradation and ease of transport through soil. The herbicide is also persistent; it has been found to be prevalent in spinach, radishes, wheat and carrots that were planted 120 days after the treatment of the herbicide.<ref name=PAN/> Its persistent nature can also be observed by its ] which varies from 3 to 70 days depending on the soil type and organic matter content.<ref name=PAN/> Residues can remain in frozen food for up to two years and the chemical is not easily destroyed by cooking the food item in boiling water.<ref name=monograph /> The EPA classifies the chemical as 'persistent' and 'mobile' based on its lack of degradation and ease of transport through soil.
A study to revealed the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities<ref> doi: 10.1016/j.reprotox.2011.02.004</ref> A study revealed the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities<ref>{{cite journal | doi=10.1016/j.reprotox.2011.02.004 | title=Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada | year=2011 | last1=Aris | first1=Aziz | last2=Leblanc | first2=Samuel | journal=Reproductive Toxicology | volume=31 | issue=4 | pages=528–533 | pmid=21338670 | s2cid=16144327 }}</ref>


===Exposure limits=== ===Exposure limits===
There are no exposure limits established by the ] or the ].<ref name="phytotechlab.com">{{cite web|url=http://phytotechlab.com/media/downloads/7382/P679MSDS.pdf |format=PDF |title=Chemical Identification and Company Information : DL-Phosphinothricin, Monoammonium Salt |publisher=Phytotechlab.com |accessdate=2015-04-25}}</ref> The WHO/FAO recommended acceptable daily intake (ADI) for glufosinate is 0.02&nbsp;mg/kg.<ref name=monograph /> The European Food Safety Authority has set an ADI of 0.021&nbsp;mg/kg. The Acute reference dose (ARfD) for child-bearing women is 0.021&nbsp;mg/kg.<ref name=monograph /> There are no exposure limits established by the ] or the ].<ref name="phytotechlab.com">{{cite web|url=http://phytotechlab.com/media/downloads/7382/P679MSDS.pdf |title=Chemical Identification and Company Information : DL-Phosphinothricin, Monoammonium Salt |publisher=Phytotechlab.com |access-date=2015-04-25 | url-status=dead | archive-url=https://web.archive.org/web/20160304093237/http://phytotechlab.com/media/downloads/7382/P679MSDS.pdf | archive-date=2016-03-04}}</ref> The WHO/FAO recommended acceptable daily intake (ADI) for glufosinate is 0.02&nbsp;mg/kg.<ref name=monograph /> The European Food Safety Authority has set an ADI of 0.021&nbsp;mg/kg. The Acute reference dose (ARfD) for child-bearing women is 0.021&nbsp;mg/kg.<ref name=monograph />


==Regulation== ==Regulation==
Glufosinate is a ] EPA registered chemical. It is also a California registered chemical. It is not banned in the country and it is not a ].<ref></ref> There are no exposure limits established by OSHA or the American Conference of Governmental Industrial Hygienists.<ref name="phytotechlab.com"/> Glufosinate is a ] EPA registered chemical. It is also a California registered chemical. It is not banned in the country and it is not a ].<ref>{{Cite web |url=https://croplife.org/crop-protection/regulatory/product-management/prior-informed-consent/ |title=The Rotterdam Convention on Prior Informed Consent (PIC) |access-date=2015-08-07 |archive-date=2021-09-24 |archive-url=https://web.archive.org/web/20210924070647/https://croplife.org/crop-protection/regulatory/product-management/prior-informed-consent/ |url-status=dead }}</ref> There are no exposure limits established by OSHA or the American Conference of Governmental Industrial Hygienists.<ref name="phytotechlab.com"/>


Glufosinate is registered for use as an herbicide in Europe; it was last reviewed in 2007 and that registration was set to expire in 2018.<ref>European Commission. Page accessed August 7, 2015</ref> It has been withdrawn from french market since october 24 2017 by the ANSES, french national agency for sanitarian security for food, work and environment, due to its classification as a possible reprotoxic chemical (R1b).<ref> Anses. Page accessed October 26, 2017</ref> Glufosinate is not approved for use as an herbicide in Europe; it was last reviewed in 2007 and that registration expired in 2018.<ref>European Commission. Page accessed August 7, 2015</ref> It has been withdrawn from the French market since October 24, 2017 by the ] due to its classification as a possible ] chemical (R1b).<ref>Anses. Page accessed October 26, 2017</ref>


==References== ==References==
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==External links== ==External links==
* *
* * {{cite web | url=http://www.bayercropscience.com.au/resources/uploads/TechGuide/file7787.pdf | title=Basta technical guide | url-status=dead | archive-url=https://web.archive.org/web/20160327160206/http://www.bayercropscience.com.au/resources/uploads/TechGuide/file7787.pdf | archive-date=2016-03-27}}
* {{PPDB|1540|Name=Glufosinate}} * {{PPDB|1540|Name=Glufosinate}}
* {{PPDB|372|Name=Glufosinate-ammonium}} * {{PPDB|372|Name=Glufosinate-ammonium}}
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] ]
] ]
] ]
]
]

Latest revision as of 19:02, 1 July 2024

Broad-spectrum herbicide Not to be confused with Glyphosate.
Glufosinate
Skeletal formula of glufosinate
Ball-and-stick model of the glufosinate zwitterion
Names
Preferred IUPAC name 2-Amino-4-butanoic acid
Other names Phosphinothricin
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.051.893 Edit this at Wikidata
EC Number
  • 257-102-5
KEGG
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C5H12NO4P/c1-11(9,10)3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)(H,9,10)Key: IAJOBQBIJHVGMQ-UHFFFAOYSA-N
SMILES
  • O=P(O)(CCC(C(=O)O)N)C
Properties
Chemical formula C5H12NO4P
Molar mass 181.128 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Glufosinate (also known as phosphinothricin and often sold as an ammonium salt) is a naturally occurring broad-spectrum herbicide produced by several species of Streptomyces soil bacteria. Glufosinate is a non-selective, contact herbicide, with some systemic action. Plants may also metabolize bialaphos and phosalacine, other naturally occurring herbicides, directly into glufosinate. The compound irreversibly inhibits glutamine synthetase, an enzyme necessary for the production of glutamine and for ammonia detoxification, giving it antibacterial, antifungal and herbicidal properties. Application of glufosinate to plants leads to reduced glutamine and elevated ammonia levels in tissues, halting photosynthesis and resulting in plant death.

Discovery

In the 1960s and early 1970s, scientists at University of Tübingen and at the Meiji Seika Kaisha Company independently discovered that species of Streptomyces bacteria produce a tripeptide they called bialaphos that inhibits bacteria; it consists of two alanine residues and a unique amino acid that is an analog of glutamate that they named "phosphinothricin". They determined that phosphinothricin irreversibly inhibits glutamine synthetase. Phosphinothricin was first synthesized by scientists at Hoechst in the 1970s as a racemic mixture; this racemic mixture is called glufosinate and is the commercially relevant version of the chemical.

In the late 1980s scientists discovered enzymes in these Streptomyces species that selectively inactivate free phosphinothricin; the gene encoding the enzyme that was isolated from Streptomyces hygroscopicus was called the "bialaphos resistance" or "bar" gene, and the gene encoding the enzyme in Streptomyces viridochromogenes was called "phosphinothricin acetyltransferase" or "pat". The two genes and their proteins have 80% homology on the DNA level and 86% amino acid homology, and are each 158 amino acids long.

Use

Glufosinate use in the USA in 2018

Glufosinate is a broad-spectrum herbicide that is used to control important weeds such as morning glories, hemp sesbania (Sesbania bispinosa), Pennsylvania smartweed (Polygonum pensylvanicum) and yellow nutsedge similar to glyphosate. It is applied to young plants during early development for full effectiveness. It is sold in formulations under brands including Basta, Rely, Finale, Challenge and Liberty. Glufosinate is typically used in three situations as an herbicide:

Glufosinate also has shown to provide some protection against various plant diseases, as it also acts to kill fungi and bacteria on contact.

Genetically modified crops

Genetically modified crops resistant to glufosinate were created by genetically engineering the bar or pat genes from streptomyces into the relevant crop seeds. In 1995 the first glufosinate-resistant crop, canola, was brought to market, and it was followed by corn in 1997, cotton in 2004, and soybeans in 2011.

Mode of action

Phosphinothricin is a glutamine synthetase inhibitor that binds to the glutamate site. Glufosinate-treated plants die due to a buildup of ammonia in the thylakoid lumen, leading to the uncoupling of photophosphorylation. The uncoupling of photophosphorylation causes the production of reactive oxygen species, lipid peroxidation, and membrane destruction.

Elevated levels of ammonia are detectable within one hour after application of phosphinothricin.

Toxicity

Exposure to humans in foods

As glufosinate is often used as a pre-harvest desiccant, it can be found in foods that humans ingest. Such foods include potatoes, peas, beans, corn, wheat, and barley. In addition, the chemical can be passed to humans through animals who are fed contaminated straw. Flour processed from wheat grain that contained traces of glufosinate was found to retain 10-100% of the chemicals' residues.

The herbicide is also persistent; it has been found to be prevalent in spinach, radishes, wheat and carrots that were planted 120 days after the treatment of the herbicide. Its persistent nature can also be observed by its half-life which varies from 3 to 70 days depending on the soil type and organic matter content. Residues can remain in frozen food for up to two years and the chemical is not easily destroyed by cooking the food item in boiling water. The EPA classifies the chemical as 'persistent' and 'mobile' based on its lack of degradation and ease of transport through soil. A study revealed the presence of circulating PAGMF in women with and without pregnancy, paving the way for a new field in reproductive toxicology including nutrition and utero-placental toxicities

Exposure limits

There are no exposure limits established by the Occupational Safety & Health Administration or the American Conference of Governmental Industrial Hygienists. The WHO/FAO recommended acceptable daily intake (ADI) for glufosinate is 0.02 mg/kg. The European Food Safety Authority has set an ADI of 0.021 mg/kg. The Acute reference dose (ARfD) for child-bearing women is 0.021 mg/kg.

Regulation

Glufosinate is a United States Environmental Protection Agency EPA registered chemical. It is also a California registered chemical. It is not banned in the country and it is not a PIC pesticide. There are no exposure limits established by OSHA or the American Conference of Governmental Industrial Hygienists.

Glufosinate is not approved for use as an herbicide in Europe; it was last reviewed in 2007 and that registration expired in 2018. It has been withdrawn from the French market since October 24, 2017 by the Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail due to its classification as a possible reprotoxic chemical (R1b).

References

  1. "glufosinate-ammonium". PPDB: Pesticide Properties DataBase.
  2. Schwartz, D.; Berger, S.; Heinzelmann, E.; Muschko, K.; Welzel, K.; Wohlleben, W. (2004). "Biosynthetic Gene Cluster of the Herbicide Phosphinothricin Tripeptide from Streptomyces viridochromogenes Tu494". Applied and Environmental Microbiology. 70 (12): 7093–7102. Bibcode:2004ApEnM..70.7093S. doi:10.1128/AEM.70.12.7093-7102.2004. PMC 535184. PMID 15574905.
  3. ^ Topsy Jewell for Friends of the Earth (December 1998). "Glufosinate ammonium fact sheet". Pesticides News No.42. Archived from the original on 2015-07-01.
  4. ^ Donn, G and Köcher, H. Inhibitors of Glutamine Synthetase. Chapter 4 in Herbicide Classes in Development: Mode of Action, Targets, Genetic Engineering, Chemistry. Eds Peter Böger, Ko Wakabayashi, Kenji Hirai. Springer Science & Business Media, 2012 ISBN 9783642594168
  5. "The agronomic benefits of glyphosate in Europe" (PDF). Monsanto Europe SA. February 2010. Archived from the original (PDF) on 2012-01-17.
  6. ^ Duke, SO. Biotechnology: Herbicide Resistant Crops. In Encyclopedia of Agriculture and Food Systems, 2nd edition. Ed. Neal K. Van Alfen. Elsevier, 2014. ISBN 9780080931395. Page 97
  7. ^ Green JM and Castle LA. Transitioning from Single to Multiple Herbicide-resistant Crops. Chapter 4 in Glyphosate Resistance in Crops and Weeds: History, Development, and Management. Editor, Vijay K. Nandula. John Wiley & Sons, 2010 ISBN 9781118043547 Page 112
  8. Summary of Herbicide Mechanism of Action, HRAC and WSSA
  9. ^ Watts, Meriel. "Glufosinate Ammonium Monograph" (PDF). Pesticide Action Network Asia and the Pacific. Retrieved 20 April 2015.
  10. Aris, Aziz; Leblanc, Samuel (2011). "Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada". Reproductive Toxicology. 31 (4): 528–533. doi:10.1016/j.reprotox.2011.02.004. PMID 21338670. S2CID 16144327.
  11. ^ "Chemical Identification and Company Information : DL-Phosphinothricin, Monoammonium Salt" (PDF). Phytotechlab.com. Archived from the original (PDF) on 2016-03-04. Retrieved 2015-04-25.
  12. "The Rotterdam Convention on Prior Informed Consent (PIC)". Archived from the original on 2021-09-24. Retrieved 2015-08-07.
  13. European Commission. Glufosinate in EU Pesticides Database Page accessed August 7, 2015
  14. Anses. L’Anses procède au retrait de l’autorisation de mise sur le marché du Basta F1, un produit phytopharmaceutique à base de glufosinate Page accessed October 26, 2017

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Glutamate metabolism and transport modulators
Transporter
EAATsTooltip Excitatory amino acid transporters
vGluTsTooltip Vesicular glutamate transporters
Enzyme
GAHTooltip Glutamine aminohydrolase (glutaminase)
ASTTooltip Aspartate aminotransferase
ALTTooltip Alanine aminotransferase
GDHTooltip Glutamate dehydrogenase
GSTooltip Glutamine synthetase
GADTooltip Glutamate decarboxylase
See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators
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