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Cefotiam

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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 20:49, 10 November 2011 (Script assisted update of identifiers for the Chem/Drugbox validation project (updated: '').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 20:49, 10 November 2011 by Beetstra (talk | contribs) (Script assisted update of identifiers for the Chem/Drugbox validation project (updated: '').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Cefotiam
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Intravenous, intramuscular
ATC code
Pharmacokinetic data
Bioavailability60% (intramuscular)
Protein binding40%
MetabolismNil
Elimination half-lifeApproximately 1 hour
ExcretionRenal
Identifiers
IUPAC name
  • (6R,7R)-7-{
    amino}-3-{
    sulfanylmethyl}-8-oxo-5-thia-1-azabicyclo
    oct-2-ene-2-carboxylic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.205.922 Edit this at Wikidata
Chemical and physical data
FormulaC18H23N9O4S3
Molar mass525.631 g/mol g·mol
3D model (JSmol)
SMILES
  • O=C2N1/C(=C(\CS12NC(=O)Cc3nc(sc3)N)CSc4nnnn4CCN(C)C)C(=O)O
InChI
  • InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
  • Key:QYQDKDWGWDOFFU-IUODEOHRSA-N
  (verify)

Cefotiam is a second-generation cephalosporin antibiotic.

External links

  • Müller R, Böttger C, Wichmann G (2003). "Suitability of cefotiam and cefuroxime axetil for the perioperative short-term prophylaxis in tonsillectomy patients". Arzneimittelforschung. 53 (2): 126–32. PMID 12642969.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Kolben M, Mandoki E, Ulm K, Freitag K (2001). "Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section". Eur J Clin Microbiol Infect Dis. 20 (1): 40–2. doi:10.1007/s100960000365. PMID 11245321.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Shimizu S, Chen K, Miyakawa S (1996). "Cefotiam-induced contact urticaria syndrome: an occupational condition in Japanese nurses". Dermatology. 192 (2): 174–6. doi:10.1159/000246352. PMID 8829507.{{cite journal}}: CS1 maint: multiple names: authors list (link)
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Antibacterials active on the cell wall and envelope (J01C-J01D)
β-lactams
(inhibit synthesis
of peptidoglycan
layer of bacterial
cell wall by binding
to and inhibiting
PBPs, a group of
D-alanyl-D-alanine
transpeptidases
)
Penicillins (Penams)
Narrow
spectrum
β-lactamase sensitive
(1st generation)
β-lactamase resistant
(2nd generation)
Extended
spectrum
Aminopenicillins (3rd generation)
Carboxypenicillins (4th generation)
Ureidopenicillins (4th generation)
Other
Carbapenems / Penems
Cephems
Cephalosporins
Cephamycins
Carbacephems
1st generation
2nd generation
3rd generation
4th generation
5th generation
Siderophore
Veterinary
Monobactams
β-lactamase inhibitors
Combinations
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Other
  • Inhibits PG elongation and crosslinking: Ramoplanin
Intracellular
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