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Auxiliary Activity family 9 (formerly GH61) is a family of lytic polysaccharide monooxygenases. The family was previously incorrectly classified as glycoside hydrolase family 61, however it was re-classified in March 2013.

AA9 is known to be a copper dependent, oxidative enzyme able to cleave crystalline cellulose. Activity greatly depends on the presence of a divalent copper ion and a reductant such as gallate or ascorbate. The oxidative action of AA9 can work on either the reducing or the non-reducing end of glucose moieties. Although AA9 enzymes can be found in a large spectrum of biomass degrading fungi, research into this family is relatively new. This classification is available on the CAZy web site, and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.

References

1. Levasseur, Anthony; Drula, Elodie; Lombard, Vincent; Coutinho, Pedro M.; Henrissat, Bernard (2013-03-21). "Expansion of the enzymatic repertoire of the CAZy database to integrate auxiliary redox enzymes". Biotechnology for Biofuels. 6 (1): 41. doi:10.1186/1754-6834-6-41. ISSN 1754-6834. PMC 3620520. PMID 23514094.
2. Hemsworth, Glyn R; Davies, Gideon J; Walton, Paul H (2013). "Recent insights into copper-containing lytic polysaccharide mono-oxygenases". Current Opinion in Structural Biology. 23 (5): 660–668. doi:10.1016/j.sbi.2013.05.006. PMID 23769965.
3. Vaaje-Kolstad, Gustav; Westereng, Bjørge; Horn, Svein J.; Liu, Zhanliang; Zhai, Hong; Sørlie, Morten; Eijsink, Vincent G. H. (2010-10-08). "An Oxidative Enzyme Boosting the Enzymatic Conversion of Recalcitrant Polysaccharides". Science. 330 (6001): 219–222. Bibcode:2010Sci...330..219V. doi:10.1126/science.1192231. ISSN 0036-8075. PMID 20929773. S2CID 206527624.
4. Bey, Mathieu; Zhou, Simeng; Poidevin, Laetitia; Henrissat, Bernard; Coutinho, Pedro M.; Berrin, Jean-Guy; Sigoillot, Jean-Claude (2013-01-15). "Cello-Oligosaccharide Oxidation Reveals Differences between Two Lytic Polysaccharide Monooxygenases (Family GH61) from Podospora anserina". Applied and Environmental Microbiology. 79 (2): 488–496. Bibcode:2013ApEnM..79..488B. doi:10.1128/aem.02942-12. ISSN 0099-2240. PMC 3553762. PMID 23124232.
5. "Home". CAZy.org. Retrieved 2018-03-06.
6. Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
7. "Auxiliary Activity Family 9". CAZypedia.org. Retrieved 2018-03-08.
8. "Glycoside Hydrolase Family 61". CAZypedia.org. Retrieved 2018-03-06.
9. CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes" (PDF). Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.

• Biology

• EC 3.2.1
• Glycoside hydrolase families
• Protein families