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Bacterial initiation factor 1 is a bacterial initiation factor.

IF1 associates with the 30S ribosomal subunit in the A site and prevents an aminoacyl-tRNA from entering. It modulates IF2 binding to the ribosome by increasing its affinity. It may also prevent the 50S subunit from binding, stopping the formation of the 70S subunit. It also contains a β-domain fold common for nucleic acid binding proteins.

IF1–IF3 may also perform ribosome recycling.

References

1. Prokaryotic+Initiation+Factor-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
2. Pavlov MY, Antoun A, Lovmar M, Ehrenberg M (June 2008). "Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting". The EMBO Journal. 27 (12): 1706–1717. doi:10.1038/emboj.2008.99. PMC 2435134. PMID 18497739.

• Protein biosynthesis
• Gene expression