Iota-carrageenase

Identifiers

Databases

PDB structures

Iota-carrageenase (EC 3.2.1.157) is an enzyme with systematic name iota-carrageenan 4-beta-D-glycanohydrolase (configuration-inverting). This enzyme catalyses the following chemical reaction

Endohydrolysis of (1->4)-beta-D-linkages between D-galactose 4-sulfate and 3,6-anhydro-D-galactose-2-sulfate in iota-carrageenans

The main products of hydrolysis are iota-neocarratetraose sulfate and iota-neocarrahexaose sulfate.

References

Barbeyron T, Michel G, Potin P, Henrissat B, Kloareg B (November 2000). "iota-Carrageenases constitute a novel family of glycoside hydrolases, unrelated to that of kappa-carrageenases". The Journal of Biological Chemistry. 275 (45): 35499–505. doi:10.1074/jbc.m003404200. PMID 10934194.
Michel G, Chantalat L, Fanchon E, Henrissat B, Kloareg B, Dideberg O (October 2001). "The iota-carrageenase of Alteromonas fortis. A beta-helix fold-containing enzyme for the degradation of a highly polyanionic polysaccharide". The Journal of Biological Chemistry. 276 (43): 40202–9. doi:10.1074/jbc.M100670200. PMID 11493601.
Michel G, Helbert W, Kahn R, Dideberg O, Kloareg B (November 2003). "The structural bases of the processive degradation of iota-carrageenan, a main cell wall polysaccharide of red algae". Journal of Molecular Biology. 334 (3): 421–33. doi:10.1016/j.jmb.2003.09.056. PMID 14623184.

Iota-carrageenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Hydrolase: sugar hydrolases (EC 3.2)

Disaccharidase	Sucrase/Sucrase-isomaltase/Invertase Maltase Trehalase Lactase
Glucosidases	Cellulase Alpha-glucosidase Acid Neutral AB Neutral C Beta-glucosidase cytosolic Debranching enzyme
Other	Amylase Alpha-amylase Chitinase Lysozyme Neuraminidase NEU1 NEU2 NEU3 NEU4 Bacterial neuraminidase Viral neuraminidase Galactosidases Alpha Beta alpha-Mannosidase Glucuronidase Klotho Hyaluronidase Pullulanase Glucosylceramidase lysosomal non-lysosomal Galactosylceramidase Alpha-N-acetylgalactosaminidase NAGA Alpha-N-acetylglucosaminidase Fucosidase Hexosaminidase HEXA HEXB Iduronidase Maltase-glucoamylase Heparanase HPSE2

3.2.2: Hydrolysing
N-Glycosyl compounds

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)