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In enzymology, a methylthioadenosine nucleosidase (EC 3.2.2.16) is an enzyme that catalyzes the chemical reaction

S-methyl-5'-thioadenosine + H₂O ${\displaystyle \rightleftharpoons }$ S-methyl-5-thio-D-ribose + adenine

Thus, the two substrates of this enzyme are S-methyl-5'-thioadenosine and H₂O, whereas its two products are S-methyl-5-thio-D-ribose and adenine.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is S-methyl-5'-thioadenosine adeninehyrolase. Other names in common use include 5'-methylthioadenosine nucleosidase, MTA nucleosidase, MeSAdo nucleosidase, and methylthioadenosine methylthioribohydrolase. This enzyme participates in urea cycle and metabolism of amino groups and methionine metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1NC1, 1NC3, 1Y6Q, 1Y6R, 1ZOS, and 2H8G.

References

• Guranowski AB, Chiang PK, Cantoni GL (1981). "5'-Methylthioadenosine nucleosidase. Purification and characterization of the enzyme from Lupinus luteus seeds". Eur. J. Biochem. 114 (2): 293–9. doi:10.1111/j.1432-1033.1981.tb05148.x. PMID 6783408.

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