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In enzymology, a NMN nucleosidase (EC 3.2.2.14) is an enzyme that catalyzes the chemical reaction

nicotinamide D-ribonucleotide + H₂O ${\displaystyle \rightleftharpoons }$ D-ribose 5-phosphate + nicotinamide

Thus, the two substrates of this enzyme are nicotinamide D-ribonucleotide and H₂O, whereas its two products are D-ribose 5-phosphate and nicotinamide.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is nicotinamide-nucleotide phosphoribohydrolase. Other names in common use include NMNase, nicotinamide mononucleotide nucleosidase, nicotinamide mononucleotidase, NMN glycohydrolase, and NMNGhase. This enzyme participates in nicotinate and nicotinamide metabolism.

References

• Andreoli AJ, Okita TW, Bloom R, Grover TA (1972). "The pyridine nucleotide cycle: presence of a nicotinamide mononucleotide-specific glycohydrolase in Escherichia coli". Biochem. Biophys. Res. Commun. 49 (1): 264–9. doi:10.1016/0006-291X(72)90039-3. PMID 4342726.

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