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In enzymology, a pyrimidine-5'-nucleotide nucleosidase (EC 3.2.2.10) is an enzyme that catalyzes the chemical reaction

a pyrimidine 5'-nucleotide + H₂O ${\displaystyle \rightleftharpoons }$ D-ribose 5-phosphate + a pyrimidine base

Thus, the two substrates of this enzyme are pyrimidine 5'-nucleotide and H₂O, whereas its two products are D-ribose 5-phosphate and pyrimidine base.

This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is pyrimidine-5'-nucleotide phosphoribo(deoxyribo)hydrolase. Other names in common use include pyrimidine nucleotide N-ribosidase, and Pyr5N. This enzyme participates in pyrimidine metabolism.

References

• Imada A (1967). "Degradation of pyrimidine nucleotides by enzyme systems of Streptomyces. II. Pyrimidine 5'-nucleotide phosphoribo(deoxyribo) hydrolase of Streptomyces virginiae". J. Gen. Appl. Microbiol. 13 (3): 267–278. doi:10.2323/jgam.13.267.
• Imada A, Kuno M, Igarasi S (1967). "Degradation of pyrimidine nucleotides by enzyme systems of Streptomyces. I. Ribose-5-phosphate formation from pyrimidine nucleotides". J. Gen. Appl. Microbiol. 13 (3): 255–265. doi:10.2323/jgam.13.255.

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