40S ribosomal protein S27a - Misplaced Pages

(Redirected from RPS27A (gene)) Protein-coding gene in the species Homo sapiens

RPS27A

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2KTF, 2L0F, 2L0T, 2XK5, 3AXC, 3NHE, 3NOB, 3PHW, 3TBL, 4UG0, 4V6X, 5AJ0, 4R62, 5FLX, 4UJD, 4KZZ, 4UJC, 3J7P, 4KZY, 4D5L, 3J7R, 4D61, 4KZX, 4UJE, 5A2Q

Identifiers

Aliases

RPS27A, CEP80, HEL112, S27A, UBA80, UBC, UBCEP1, UBCEP80, ribosomal protein S27a

External IDs

OMIM: 191343; MGI: 1925544; HomoloGene: 37715; GeneCards: RPS27A; OMA:RPS27A - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2p16.1	Start	55,231,903 bp
Band	2p16.1	End	55,235,853 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 A3.3	Start	29,495,846 bp
Band	11\|11 A3.3	End	29,498,109 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

left ovary

granulocyte

ganglionic eminence

right uterine tube

canal of the cervix

right ovary

body of uterus

ventricular zone

left lobe of thyroid gland

anterior pituitary

Top expressed in

embryo

embryo

epiblast

urinary bladder

bone marrow

ventricular zone

uterus

pancreas

adrenal gland

lens

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	metal ion binding structural constituent of ribosome protein binding RNA binding protein tag ubiquitin protein ligase binding
Cellular component	cytoplasm endocytic vesicle membrane cytosol membrane nucleus ribosome myelin sheath cytosolic small ribosomal subunit nucleolus extracellular exosome plasma membrane nucleoplasm small ribosomal subunit endosome membrane extracellular space mitochondrial outer membrane endoplasmic reticulum quality control compartment vesicle endoplasmic reticulum membrane host cell
Biological process	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest negative regulation of epidermal growth factor receptor signaling pathway interstrand cross-link repair nucleotide-excision repair, DNA damage recognition positive regulation of canonical Wnt signaling pathway tumor necrosis factor-mediated signaling pathway regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway endosomal transport global genome nucleotide-excision repair NIK/NF-kappaB signaling G2/M transition of mitotic cell cycle stress-activated MAPK cascade transforming growth factor beta receptor signaling pathway macroautophagy negative regulation of canonical Wnt signaling pathway nucleotide-excision repair, DNA gap filling viral transcription error-free translesion synthesis regulation of tumor necrosis factor-mediated signaling pathway stimulatory C-type lectin receptor signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway SRP-dependent cotranslational protein targeting to membrane JNK cascade regulation of transcription from RNA polymerase II promoter in response to hypoxia nucleotide-excision repair, DNA incision I-kappaB kinase/NF-kappaB signaling innate immune response Notch signaling pathway regulation of mRNA stability protein polyubiquitination negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II virion assembly positive regulation of NF-kappaB transcription factor activity anaphase-promoting complex-dependent catabolic process negative regulation of type I interferon production nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nucleotide-binding oligomerization domain containing signaling pathway intracellular transport of virus viral life cycle MyD88-dependent toll-like receptor signaling pathway error-prone translesion synthesis MAPK cascade fibroblast growth factor receptor signaling pathway ion transmembrane transport glycogen biosynthetic process positive regulation of apoptotic process translational initiation positive regulation of I-kappaB kinase/NF-kappaB signaling translesion synthesis transcription-coupled nucleotide-excision repair T cell receptor signaling pathway MyD88-independent toll-like receptor signaling pathway positive regulation of transcription by RNA polymerase II regulation of signal transduction by p53 class mediator positive regulation of epidermal growth factor receptor signaling pathway Wnt signaling pathway nucleotide-excision repair, DNA duplex unwinding nucleotide-excision repair, DNA incision, 5'-to lesion protein biosynthesis rRNA processing ERBB2 signaling pathway Wnt signaling pathway, planar cell polarity pathway nucleotide-excision repair, preincision complex assembly proteasome-mediated ubiquitin-dependent protein catabolic process protein folding negative regulation of G2/M transition of mitotic cell cycle protein ubiquitination protein deubiquitination SCF-dependent proteasomal ubiquitin-dependent protein catabolic process entry of bacterium into host cell transmembrane transport regulation of necroptotic process membrane organization endoplasmic reticulum mannose trimming cellular iron ion homeostasis regulation of hematopoietic stem cell differentiation protein targeting to peroxisome cytokine-mediated signaling pathway modification-dependent protein catabolic process interleukin-1-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6233


78294

Ensembl


ENSG00000143947


ENSMUSG00000020460

UniProt


P62979


P62983

RefSeq (mRNA)


NM_002954 NM_001135592 NM_001177413


NM_001033865 NM_024277

RefSeq (protein)


NP_001129064 NP_001170884 NP_002945


NP_001029037 NP_077239

Location (UCSC)

Chr 2: 55.23 – 55.24 Mb

Chr 11: 29.5 – 29.5 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.

Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi.

References

^ GRCh38: Ensembl release 89: ENSG00000143947 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000020460 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ "Entrez Gene: RPS27A ribosomal protein S27a".

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Adams SM, Sharp MG, Walker RA, et al. (1992). "Differential expression of translation-associated genes in benign and malignant human breast tumours". Br. J. Cancer. 65 (1): 65–71. doi:10.1038/bjc.1992.12. PMC 1977345. PMID 1370760.
Pancré V, Pierce RJ, Fournier F, et al. (1991). "Effect of ubiquitin on platelet functions: possible identity with platelet activity suppressive lymphokine (PASL)". Eur. J. Immunol. 21 (11): 2735–41. doi:10.1002/eji.1830211113. PMID 1657614. S2CID 23901646.
Kanayama H, Tanaka K, Aki M, et al. (1992). "Changes in expressions of proteasome and ubiquitin genes in human renal cancer cells". Cancer Res. 51 (24): 6677–85. PMID 1660345.
Monia BP, Ecker DJ, Jonnalagadda S, et al. (1989). "Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins". J. Biol. Chem. 264 (7): 4093–103. doi:10.1016/S0021-9258(19)84967-0. PMID 2537304.
Redman KL, Rechsteiner M (1989). "Identification of the long ubiquitin extension as ribosomal protein S27a". Nature. 338 (6214): 438–40. Bibcode:1989Natur.338..438R. doi:10.1038/338438a0. PMID 2538756. S2CID 4360107.
Lund PK, Moats-Staats BM, Simmons JG, et al. (1985). "Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor". J. Biol. Chem. 260 (12): 7609–13. doi:10.1016/S0021-9258(17)39652-7. PMID 2581967.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kirschner LS, Stratakis CA (2000). "Structure of the human ubiquitin fusion gene Uba80 (RPS27a) and one of its pseudogenes". Biochem. Biophys. Res. Commun. 270 (3): 1106–10. doi:10.1006/bbrc.2000.2568. PMID 10772958.
Petersen BO, Wagener C, Marinoni F, et al. (2000). "Cell cycle– and cell growth–regulated proteolysis of mammalian CDC6 is dependent on APC–CDH1". Genes Dev. 14 (18): 2330–43. doi:10.1101/gad.832500. PMC 316932. PMID 10995389.
Bolton D, Evans PA, Stott K, Broadhurst RW (2002). "Structure and properties of a dimeric N-terminal fragment of human ubiquitin". J. Mol. Biol. 314 (4): 773–87. doi:10.1006/jmbi.2001.5181. PMID 11733996.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cohen BD, Bariteau JT, Magenis LM, Dias JA (2003). "Regulation of follitropin receptor cell surface residency by the ubiquitin-proteasome pathway". Endocrinology. 144 (10): 4393–402. doi:10.1210/en.2002-0063. PMID 12960054.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.

v t e PDB gallery
1aar: STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2) 1cmx: STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES 1d3z: UBIQUITIN NMR STRUCTURE 1f9j: STRUCTURE OF A NEW CRYSTAL FORM OF TETRAUBIQUITIN 1fxt: STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX 1g6j: STRUCTURE OF RECOMBINANT HUMAN UBIQUITIN IN AOT REVERSE MICELLES 1gjz: SOLUTION STRUCTURE OF A DIMERIC N-TERMINAL FRAGMENT OF HUMAN UBIQUITIN 1nbf: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde 1ogw: SYNTHETIC UBIQUITIN WITH FLUORO-LEU AT 50 AND 67 1otr: Solution Structure of a CUE-Ubiquitin Complex 1p3q: Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9 1q0w: Solution structure of Vps27 amino-terminal UIM-ubiquitin complex 1q5w: Ubiquitin Recognition by Npl4 Zinc-Fingers 1s1q: TSG101(UEV) domain in complex with Ubiquitin 1sif: Crystal structure of a multiple hydrophobic core mutant of ubiquitin 1tbe: STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED 1ubi: SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1 1ubq: STRUCTURE OF UBIQUITIN REFINED AT 1.8 ANGSTROMS RESOLUTION 1ud7: SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7 1uzx: A COMPLEX OF THE VPS23 UEV WITH UBIQUITIN 1v80: Solution structures of ubiquitin at 30 bar and 3 kbar 1v81: Solution structures of ubiquitin at 30 bar and 3 kbar 1wr1: The complex structure of Dsk2p UBA with ubiquitin 1wr6: Crystal structure of GGA3 GAT domain in complex with ubiquitin 1wrd: Crystal structure of Tom1 GAT domain in complex with ubiquitin 1xd3: Crystal structure of UCHL3-UbVME complex 1xqq: Simultaneous determination of protein structure and dynamics 1yd8: COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN 1yiw: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin 1yj1: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin 1yx5: Solution Structure of S5a UIM-1/Ubiquitin Complex 1yx6: Solution Structure of S5a UIM-2/Ubiquitin Complex 1zgu: Solution structure of the human Mms2-Ubiquitin complex 2ayo: Structure of USP14 bound to ubquitin aldehyde 2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN USING CHEMICAL SHIFT PERTURBATION DATA TOGETHER WITH RDCS AND 15N-RELAXATION DATA 2c7m: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN 2c7n: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN 2d3g: Double sided ubiquitin binding of Hrs-UIM 2den: Solution Structure of the Ubiquitin-Associated Domain of Human BMSC-UbP and its Complex with Ubiquitin 2dx5: The complex structure between the mouse EAP45-GLUE domain and ubiquitin 2fcm: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group 2fcn: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group 2fcq: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group 2fcs: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group 2fid: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin 2fif: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin 2fuh: Solution Structure of the UbcH5c/Ub Non-covalent Complex 2g3q: Solution Structure of Ede1 UBA-ubiquitin complex 2g45: Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin 2gbj: Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin. 2gbk: Crystal Structure of the 9-10 MoaD Insertion Mutant of Ubiquitin 2gbm: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin 2gbn: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin 2gbr: Crystal Structure of the 35-36 MoaD Insertion Mutant of Ubiquitin 2gmi: Mms2/Ubc13~Ubiquitin 2hd5: USP2 in complex with ubiquitin 2hth: Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain 2ibi: Covalent Ubiquitin-USP2 Complex 2j7q: CRYSTAL STRUCTURE OF THE UBIQUITIN-SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN M48 IN COMPLEX WITH A UBQUITIN-BASED SUICIDE SUBSTRATE 2nr2: The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native states ensembles of proteins 2o6v: Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH 2oob: crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin

PDB gallery

1aar: STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)
1cmx: STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES
1d3z: UBIQUITIN NMR STRUCTURE
1f9j: STRUCTURE OF A NEW CRYSTAL FORM OF TETRAUBIQUITIN
1fxt: STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX
1g6j: STRUCTURE OF RECOMBINANT HUMAN UBIQUITIN IN AOT REVERSE MICELLES
1gjz: SOLUTION STRUCTURE OF A DIMERIC N-TERMINAL FRAGMENT OF HUMAN UBIQUITIN
1nbf: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
1ogw: SYNTHETIC UBIQUITIN WITH FLUORO-LEU AT 50 AND 67
1otr: Solution Structure of a CUE-Ubiquitin Complex
1p3q: Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9
1q0w: Solution structure of Vps27 amino-terminal UIM-ubiquitin complex
1q5w: Ubiquitin Recognition by Npl4 Zinc-Fingers
1s1q: TSG101(UEV) domain in complex with Ubiquitin
1sif: Crystal structure of a multiple hydrophobic core mutant of ubiquitin
1tbe: STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED
1ubi: SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1
1ubq: STRUCTURE OF UBIQUITIN REFINED AT 1.8 ANGSTROMS RESOLUTION
1ud7: SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7
1uzx: A COMPLEX OF THE VPS23 UEV WITH UBIQUITIN
1v80: Solution structures of ubiquitin at 30 bar and 3 kbar
1v81: Solution structures of ubiquitin at 30 bar and 3 kbar
1wr1: The complex structure of Dsk2p UBA with ubiquitin
1wr6: Crystal structure of GGA3 GAT domain in complex with ubiquitin
1wrd: Crystal structure of Tom1 GAT domain in complex with ubiquitin
1xd3: Crystal structure of UCHL3-UbVME complex
1xqq: Simultaneous determination of protein structure and dynamics
1yd8: COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN
1yiw: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin
1yj1: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin
1yx5: Solution Structure of S5a UIM-1/Ubiquitin Complex
1yx6: Solution Structure of S5a UIM-2/Ubiquitin Complex
1zgu: Solution structure of the human Mms2-Ubiquitin complex
2ayo: Structure of USP14 bound to ubquitin aldehyde
2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN USING CHEMICAL SHIFT PERTURBATION DATA TOGETHER WITH RDCS AND 15N-RELAXATION DATA
2c7m: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN
2c7n: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN
2d3g: Double sided ubiquitin binding of Hrs-UIM
2den: Solution Structure of the Ubiquitin-Associated Domain of Human BMSC-UbP and its Complex with Ubiquitin
2dx5: The complex structure between the mouse EAP45-GLUE domain and ubiquitin
2fcm: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group
2fcn: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group
2fcq: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group
2fcs: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group
2fid: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
2fif: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin
2fuh: Solution Structure of the UbcH5c/Ub Non-covalent Complex
2g3q: Solution Structure of Ede1 UBA-ubiquitin complex
2g45: Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin
2gbj: Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin.
2gbk: Crystal Structure of the 9-10 MoaD Insertion Mutant of Ubiquitin
2gbm: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin
2gbn: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin
2gbr: Crystal Structure of the 35-36 MoaD Insertion Mutant of Ubiquitin
2gmi: Mms2/Ubc13~Ubiquitin
2hd5: USP2 in complex with ubiquitin
2hth: Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain
2ibi: Covalent Ubiquitin-USP2 Complex
2j7q: CRYSTAL STRUCTURE OF THE UBIQUITIN-SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN M48 IN COMPLEX WITH A UBQUITIN-BASED SUICIDE SUBSTRATE
2nr2: The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native states ensembles of proteins
2o6v: Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH
2oob: crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin

Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)

Proteins

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X, RPS4Y1, RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35