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rpoE

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The gene rpoE (RNA polymerase, extracytoplasmic E) encodes the sigma factor sigma-24 (σ24, sigma E, or RpoE), a protein in Escherichia coli and other species of bacteria. Depending on the bacterial species, this gene may be referred to as sigE.

RpoE appears to be necessary for the exocytoplasmic stress response. E. coli mutants without rpoE cannot grow at high temperatures (that is, above 42 degrees C) and show growth defects at lower temperatures, though this may be due to compensatory mutations. In some bacterial species, such as Clostridium botulinum, this sigma factor may be necessary for sporulation.

The stress response regulation activities of RpoE are modulated by the Hfq protein in E. coli.

References

  1. Rouvière, PE; De Las Peñas, A; Mecsas, J; Lu, CZ; Rudd, KE; Gross, CA (1995). "rpoE, the gene encoding the second heat-shock sigma factor, sigma E, in Escherichia coli". The EMBO Journal. 14 (5): 1032–42. doi:10.1002/j.1460-2075.1995.tb07084.x. PMC 398175. PMID 7889934.
  2. Jensen-Cain, DM; Quinn, FD (2001). "Differential expression of sigE by Mycobacterium tuberculosis during intracellular growth". Microbial Pathogenesis. 30 (5): 271–8. doi:10.1006/mpat.2001.0431. PMID 11373121.
  3. Hiratsu, K; Amemura, M; Nashimoto, H; Shinagawa, H; Makino, K (1995). "The rpoE gene of Escherichia coli, which encodes sigma E, is essential for bacterial growth at high temperature". Journal of Bacteriology. 177 (10): 2918–22. doi:10.1128/jb.177.10.2918-2922.1995. PMC 176969. PMID 7751307.
  4. De Las Peñas, A; Connolly, L; Gross, CA (Nov 1997). "SigmaE is an essential sigma factor in Escherichia coli". Journal of Bacteriology. 179 (21): 6862–4. doi:10.1128/jb.179.21.6862-6864.1997. PMC 179621. PMID 9352942.
  5. Kirk, DG; Zhang, Z; Korkeala, H; Lindström, M (2014). "Alternative sigma factors SigF, SigE, and SigG are essential for sporulation in Clostridium botulinum ATCC 3502". Applied and Environmental Microbiology. 80 (16): 5141–50. Bibcode:2014ApEnM..80.5141K. doi:10.1128/aem.01015-14. PMC 4135750. PMID 24928875.
  6. De Las Peñas, A; Connolly, L; Gross, CA (Nov 1997). "SigmaE is an essential sigma factor in Escherichia coli". Journal of Bacteriology. 179 (21): 6862–4. doi:10.1128/jb.179.21.6862-6864.1997. PMC 179621. PMID 9352942.
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