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SNX21
Identifiers
Aliases	SNX21, C20orf161, PP3993, SNX-L, dJ337O18.4, sorting nexin family member 21, SNXL
External IDs	MGI: 1917729; HomoloGene: 43132; GeneCards: SNX21; OMA:SNX21 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 45,833,799 bp End 45,843,276 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 164,627,743 bp End 164,635,736 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg right ovary left ovary skin of abdomen right coronary artery endothelial cell right adrenal cortex gastric mucosa left adrenal cortex left uterine tube Top expressed in muscle of thigh Rostral migratory stream lip lumbar spinal ganglion superior frontal gyrus primary visual cortex facial motor nucleus right kidney cerebellar cortex neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function lipid binding phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylinositol-3-phosphate binding Cellular component membrane cytoplasmic vesicle cytoplasmic vesicle membrane endosome early endosome membrane Biological process protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90203 101113 Ensembl ENSG00000124104 ENSMUSG00000050373 UniProt Q969T3 Q3UR97 RefSeq (mRNA) NM_001042632 NM_001042633 NM_033421 NM_152897 NM_133924 NM_001399716 RefSeq (protein) NP_001036097 NP_001036098 NP_219489 NP_690857 NP_598685 NP_001386645 Location (UCSC) Chr 20: 45.83 – 45.84 Mb Chr 2: 164.63 – 164.64 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000124104 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000050373 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
6. Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.
7. ^ "Entrez Gene: SNX21 sorting nexin family member 21".

Further reading

• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.

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