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SNX4
Identifiers
Aliases	SNX4, ATG24B, sorting nexin 4
External IDs	OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3q21.2 Start 125,446,650 bp End 125,520,202 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 B3 Start 33,071,812 bp End 33,120,639 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte jejunal mucosa Achilles tendon kidney tubule ganglionic eminence ventricular zone islet of Langerhans duodenum Epithelium of choroid plexus tendon of biceps brachii Top expressed in atrioventricular valve left lung lobe endocardial cushion sciatic nerve granulocyte yolk sac vestibular sensory epithelium ureter primitive streak zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding transferrin receptor binding lipid binding Cellular component cytoplasm extrinsic component of membrane endosome early endosome membrane membrane plasma membrane SNARE complex cytoplasmic dynein complex protein-containing complex early endosome Biological process endocytosis vesicle organization endocytic recycling protein transport positive regulation of histamine secretion by mast cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8723 69150 Ensembl ENSG00000114520 ENSMUSG00000022808 UniProt O95219 Q91YJ2 RefSeq (mRNA) NM_003794 NM_080557 RefSeq (protein) NP_003785 NP_542124 Location (UCSC) Chr 3: 125.45 – 125.52 Mb Chr 16: 33.07 – 33.12 Mb PubMed search
Wikidata
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Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.

Interactions

SNX4 has been shown to interact with BIN1.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
6. ^ "Entrez Gene: SNX4 sorting nexin 4".
7. Leprince, Corinne; Le Scolan Erwan; Meunier Brigitte; Fraisier Vincent; Brandon Nathalie; De Gunzburg Jean; Camonis Jacques (May 2003). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10). England: 1937–48. doi:10.1242/jcs.00403. ISSN 0021-9533. PMID 12668730.

Further reading

• Traer CJ, Rutherford AC, Palmer KJ, et al. (2008). "SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment". Nat. Cell Biol. 9 (12): 1370–80. doi:10.1038/ncb1656. PMID 17994011. S2CID 23816176.
• Skånland SS, Wälchli S, Utskarpen A, et al. (2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl:10852/11339. PMID 17319803. S2CID 21600584.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Leprince C, Le Scolan E, Meunier B, et al. (2004). "Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking". J. Cell Sci. 116 (Pt 10): 1937–48. doi:10.1242/jcs.00403. PMID 12668730.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.

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