Misplaced Pages

Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

The common cytokine-binding domain is related to the Fibronectin type III domain.

Signal transduction chains

The signal transducing chains are often shared between different receptors within this receptor family.

• The IL-2 receptor common gamma chain (also known as CD132) is shared between:
  • IL-2 receptor
  • IL-4 receptor
  • IL-7 receptor
  • IL-9 receptor
  • IL-13 receptor
  • IL-15 receptor
  • IL-21 receptor
• The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
  • GM-CSF receptor
  • IL-3 receptor
  • IL-5 receptor.
• The gp130 receptor (Glycoprotein 130) (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
  • IL-6 receptor
  • IL-11 receptor
  • IL-12 receptor
  • IL-27 receptor
  • Leukemia inhibitory factor receptor
  • Oncostatin M receptor

Examples

Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Interleukin receptors

• Interleukin-1 receptor
• Interleukin-2 receptor
• Interleukin-3 receptor
• Interleukin-4 receptor
• Interleukin-5 receptor
• Interleukin-6 receptor
• Interleukin-7 receptor
• Interleukin-9 receptor
• Interleukin-11 receptor
• Interleukin-12 receptor
• Interleukin-13 receptor
• Interleukin-15 receptor
• Interleukin-18 receptor
• Interleukin-21 receptor
• Interleukin-23 receptor
• Interleukin-27 receptor

Colony stimulating factor receptors

• Erythropoietin receptor
• GM-CSF receptor
• G-CSF receptor
• Thrombopoietin receptor

Hormone receptor/neuropeptide receptor

• Growth hormone receptor
• Prolactin receptor
• Leptin receptor

Other

• Oncostatin M receptor
• Leukemia inhibitory factor receptor

References

1. Lichtman, Andrew H.; Abbas, Abul K. (2003). Cellular and molecular immunology (5th ed.). Philadelphia: Saunders. ISBN 0-7216-0008-5.
2. He YW, Adkins B, Furse RK, Malek TR (1995). "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor". J. Immunol. 154 (4): 1596–605. PMID 7530740.
3. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster K, Sugamura K (2001). "Cutting edge: the common γ-chain is an indispensable subunit of the IL21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623.
4. Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF (1998). "Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors". J. Biol. Chem. 273 (2): 1192–9. doi:10.1074/jbc.273.2.1192. PMID 9422786.
5. Cirillo, Donatella; Rachiglio, Anna Maria; la Montagna, Raffaele; Giordano, Antonio; Normanno, Nicola (1 November 2008). "Leptin signaling in breast cancer: An overview". Journal of Cellular Biochemistry. 105 (4): 956–964. doi:10.1002/jcb.21911. PMID 18821585.

External links

• Cytokine+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Cytokine receptors
• Type I cytokine receptors