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TNFRSF10C
Identifiers
Aliases	TNFRSF10C, CD263, DCR1, DCR1-TNFR, LIT, TRAIL-R3, TRAILR3, TRID, tumor necrosis factor receptor superfamily member 10c, TNF receptor superfamily member 10c
External IDs	OMIM: 603613; HomoloGene: 48244; GeneCards: TNFRSF10C; OMA:TNFRSF10C - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 23,102,921 bp End 23,117,445 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte testicle periodontal fiber bone marrow gonad monocyte spleen gallbladder bone marrow cells n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity tumor necrosis factor-activated receptor activity TRAIL binding Cellular component anchored component of membrane integral component of plasma membrane membrane plasma membrane cell surface Biological process multicellular organism development response to lipopolysaccharide inflammatory response regulation of cell population proliferation immune response signal transduction apoptotic process tumor necrosis factor-mediated signaling pathway apoptotic signaling pathway regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TRAIL-activated apoptotic signaling pathway positive regulation of apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8794 n/a Ensembl ENSG00000173535 n/a UniProt O14798 n/a RefSeq (mRNA) NM_003841 n/a RefSeq (protein) NP_003832 n/a Location (UCSC) Chr 8: 23.1 – 23.12 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Decoy receptor 1 (DCR1), also known as TRAIL receptor 3 (TRAILR3) and tumor necrosis factor receptor superfamily member 10C (TNFRSF10C), is a human cell surface receptor of the TNF-receptor superfamily.

Function

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000173535 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Degli-Esposti MA, Smolak PJ, Walczak H, Waugh J, Huang CP, DuBose RF, Goodwin RG, Smith CA (Nov 1997). "Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family". J Exp Med. 186 (7): 1165–70. doi:10.1084/jem.186.7.1165. PMC 2199077. PMID 9314565.
4. MacFarlane M, Ahmad M, Srinivasula SM, Fernandes-Alnemri T, Cohen GM, Alnemri ES (Nov 1997). "Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL". J Biol Chem. 272 (41): 25417–20. doi:10.1074/jbc.272.41.25417. PMID 9325248.
5. ^ "Entrez Gene: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain".

Further reading

• Kimberley FC, Screaton GR (2005). "Following a TRAIL: update on a ligand and its five receptors". Cell Res. 14 (5): 359–72. doi:10.1038/sj.cr.7290236. PMID 15538968.
• Pan G, Ni J, Wei YF, et al. (1997). "An antagonist decoy receptor and a death domain-containing receptor for TRAIL". Science. 277 (5327): 815–8. doi:10.1126/science.277.5327.815. PMID 9242610.
• Sheridan JP, Marsters SA, Pitti RM, et al. (1997). "Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors". Science. 277 (5327): 818–21. doi:10.1126/science.277.5327.818. PMID 9242611.
• Schneider P, Bodmer JL, Thome M, et al. (1997). "Characterization of two receptors for TRAIL" (PDF). FEBS Lett. 416 (3): 329–34. doi:10.1016/S0014-5793(97)01231-3. PMID 9373179. S2CID 83145771.
• Mongkolsapaya J, Cowper AE, Xu XN, et al. (1998). "Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL". J. Immunol. 160 (1): 3–6. doi:10.4049/jimmunol.160.1.3. PMID 9551946.
• Rieger J, Naumann U, Glaser T, et al. (1998). "APO2 ligand: a novel lethal weapon against malignant glioma?". FEBS Lett. 427 (1): 124–8. doi:10.1016/S0014-5793(98)00409-8. PMID 9613612. S2CID 5920531.
• Sheikh MS, Huang Y, Fernandez-Salas EA, et al. (1999). "The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract". Oncogene. 18 (28): 4153–9. doi:10.1038/sj.onc.1202763. PMID 10435597. S2CID 22315889.
• Leverkus M, Walczak H, McLellan A, et al. (2000). "Maturation of dendritic cells leads to up-regulation of cellular FLICE-inhibitory protein and concomitant down-regulation of death ligand-mediated apoptosis". Blood. 96 (7): 2628–31. doi:10.1182/blood.V96.7.2628. PMID 11001921. S2CID 42437707.
• Zhang XD, Nguyen T, Thomas WD, et al. (2000). "Mechanisms of resistance of normal cells to TRAIL induced apoptosis vary between different cell types". FEBS Lett. 482 (3): 193–9. doi:10.1016/S0014-5793(00)02042-1. PMID 11024459. S2CID 12827383.
• Dörr J, Bechmann I, Waiczies S, et al. (2002). "Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain". J. Neurosci. 22 (4): RC209. doi:10.1523/JNEUROSCI.22-04-j0001.2002. PMC 6757573. PMID 11844843.
• Liao Q, Friess H, Kleeff J, Büchler MW (2002). "Differential expression of TRAIL-R3 and TRAIL-R4 in human pancreatic cancer". Anticancer Res. 21 (5): 3153–9. PMID 11848467.
• Bretz JD, Mezosi E, Giordano TJ, et al. (2002). "Inflammatory cytokine regulation of TRAIL-mediated apoptosis in thyroid epithelial cells". Cell Death Differ. 9 (3): 274–86. doi:10.1038/sj.cdd.4400965. PMID 11859410.
• Hueber A, Aduckathil S, Kociok N, et al. (2002). "Apoptosis-mediating receptor-ligand systems in human retinal pigment epithelial cells". Graefes Arch. Clin. Exp. Ophthalmol. 240 (7): 551–6. doi:10.1007/s00417-002-0487-6. PMID 12136286. S2CID 10307168.
• Matysiak M, Jurewicz A, Jaskolski D, Selmaj K (2002). "TRAIL induces death of human oligodendrocytes isolated from adult brain". Brain. 125 (Pt 11): 2469–80. doi:10.1093/brain/awf254. PMID 12390973.
• Ruiz de Almodóvar C, López-Rivas A, Redondo JM, Rodríguez A (2002). "Transcription initiation sites and promoter structure of the human TRAIL-R3 gene". FEBS Lett. 531 (2): 304–8. doi:10.1016/S0014-5793(02)03544-5. PMID 12417331. S2CID 37720054.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ou D, Metzger DL, Wang X, et al. (2003). "TNF-related apoptosis-inducing ligand death pathway-mediated human beta-cell destruction". Diabetologia. 45 (12): 1678–88. doi:10.1007/s00125-002-0926-2. PMID 12488957.
• Hasel C, Dürr S, Rau B, et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas". Lab. Invest. 83 (6): 825–36. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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