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Bivatuzumab mertansine

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Chemical compound
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Find sources: "Bivatuzumab mertansine" – news · newspapers · books · scholar · JSTOR (August 2014)
Pharmaceutical compound
Bivatuzumab mertansine
Monoclonal antibody
TypeWhole antibody
SourceHumanized (from mouse)
TargetCD44 v6
Clinical data
ATC code
  • none
Identifiers
ChemSpider
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Bivatuzumab mertansine is a combination of bivatuzumab, a humanized monoclonal antibody, and mertansine, a cytotoxic agent. It is designed for the treatment of squamous cell carcinoma.

References

  1. Tijink BM, Buter J, de Bree R, Giaccone G, Lang MS, Staab A, et al. (October 2006). "A phase I dose escalation study with anti-CD44v6 bivatuzumab mertansine in patients with incurable squamous cell carcinoma of the head and neck or esophagus". Clinical Cancer Research. 12 (20 Pt 1): 6064–72. doi:10.1158/1078-0432.CCR-06-0910. PMID 17062682.
Monoclonal antibodies for tumors
Tumor
Human
Mouse
Chimeric
Humanized
Rat/mouse hybrid
Chimeric + humanized
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