Misplaced Pages

Conatumumab (originally AMG-655) is a monoclonal antibody developed for the treatment of cancer. It is a fully human monoclonal agonist antibody directed against the extracellular domain of human TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) receptor 2 (TR-2, death receptor 5) with potential antineoplastic activity. Conatumumab mimics the activity of native TRAIL, binding to and activating TR-2, thereby activating caspase cascades and inducing tumor cell apoptosis. TR-2 is expressed by a variety of solid tumors and cancers of hematopoietic origin.

The drug was developed by Amgen Inc. In 2008, Takeda licensed the drug from Amgen for development in Japan, but discontinued development in 2011.

References

1. Rosevear HM, Lightfoot AJ, Griffith TS (June 2010). "Conatumumab, a fully human mAb against death receptor 5 for the treatment of cancer". Current Opinion in Investigational Drugs. 11 (6). London, England: 688–98. PMID 20496264.
2. Bajaj M, Heath EI (November 2011). "Conatumumab: a novel monoclonal antibody against death receptor 5 for the treatment of advanced malignancies in adults". Expert Opinion on Biological Therapy. 11 (11): 1519–24. doi:10.1517/14712598.2011.610788. PMID 21877997. S2CID 28520935.
3. Statement On A Nonproprietary Name Adopted By The USAN Council – Conatumumab, American Medical Association.
4. National Cancer Institute: Definition of conatumomab

This monoclonal antibody–related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

This antineoplastic or immunomodulatory drug article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Drugs not assigned an ATC code
• Amgen
• Abandoned drugs
• Monoclonal antibody stubs
• Antineoplastic and immunomodulating drug stubs