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Drozitumab

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Monoclonal antibody Pharmaceutical compound
Drozitumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetDR5
Clinical data
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6334H9792N1700O2000S42
Molar mass143104.43 g·mol
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Drozitumab is a human monoclonal antibody in development for the treatment of cancers. It targets Tumour Necrosis Factor Related Apoptosis-inducing Ligand (TRAIL), whose receptors are found on the surface of many types of malignant cells. Drozitumab was developed by Genentech.

Although drozitumab was studied in phase II trials for treating chondrosarcoma, colorectal cancer, non-Hodgkin lymphoma, and non-small cell lung cancer, development has been halted due to lack of clinical response.

References

  1. "Statement On A Nonproprietary Name Adopted By The USAN Council: Drozitumab" (PDF). American Medical Association.
  2. ^ "Drozitumab". AdisInsight. Retrieved 31 January 2017.
Monoclonal antibodies for tumors
Tumor
Human
Mouse
Chimeric
Humanized
Rat/mouse hybrid
Chimeric + humanized


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