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Ccl12
Identifiers
Aliases	chemokine (C-C motif) ligand 12MCP-5Scya12
External IDs	HomoloGene: 2245; GeneCards: ; OMA:- orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11 C|11 49.9 cM Start 81,992,671 bp End 81,994,226 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cervix right kidney embryo thymus subcutaneous adipose tissue aortic valve stroma of bone marrow dermis efferent ductule white adipose tissue n/a More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity CCR2 chemokine receptor binding chemokine activity protein kinase activity phospholipase activator activity CCR chemokine receptor binding Cellular component extracellular region intracellular anatomical structure extracellular space Biological process negative regulation of neuron apoptotic process G protein-coupled receptor signaling pathway protein kinase B signaling monocyte chemotaxis astrocyte cell migration cytokine-mediated signaling pathway chemokine-mediated signaling pathway negative regulation of glial cell apoptotic process cellular response to tumor necrosis factor negative regulation of natural killer cell chemotaxis cellular response to organic cyclic compound neutrophil chemotaxis MAPK cascade chemotaxis positive regulation of GTPase activity positive regulation of calcium ion import macrophage chemotaxis cytoskeleton organization angiogenesis immune response cellular response to interleukin-1 positive regulation of ERK1 and ERK2 cascade regulation of cell shape cellular response to interferon-gamma lymphocyte chemotaxis inflammatory response lipopolysaccharide-mediated signaling pathway regulation of signaling receptor activity positive regulation of leukocyte migration negative regulation of leukocyte proliferation negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process calcium ion transport cellular calcium ion homeostasis exocytosis cell-cell signaling eosinophil chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 20293 n/a Ensembl ENSMUSG00000035352 n/a UniProt Q62401 n/a RefSeq (mRNA) NM_011331 n/a RefSeq (protein) NP_035461 n/a Location (UCSC) Chr 11: 81.99 – 81.99 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 12 (CCL12) is a small cytokine belonging to the CC chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts eosinophils, monocytes and lymphocytes. This chemokine is found predominantly in lymph nodes and thymus under normal conditions, and its expression can be hugely induced in macrophages. It is thought to coordinate cell movements during early allergic reactions, and immune response to pathogens. The gene for CCL12 is found in a cluster of CC chemokines on mouse chromosome 11.

References

1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
2. ^ Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J (1996). "Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation". J Exp Med. 184 (5): 1939–51. doi:10.1084/jem.184.5.1939. PMC 2192876. PMID 8920881.
3. ^ Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A (1997). "Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1". J Exp Med. 185 (1): 99–109. doi:10.1084/jem.185.1.99. PMC 2196097. PMID 8996246.

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