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CCL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B50, 1B53, 2X69, 2X6G, 3FPU, 3H44, 3KBX, 4RA8, 4ZKB, 5D65, 5COR
Identifiers
Aliases	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3, C-C motif chemokine ligand 3
External IDs	OMIM: 182283; MGI: 98260; HomoloGene: 88430; GeneCards: CCL3; OMA:CCL3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q12 Start 36,088,256 bp End 36,090,169 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 C|11 51.04 cM Start 83,538,670 bp End 83,540,181 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow granulocyte spleen monocyte bone marrow cells gallbladder placenta testicle lymph node appendix Top expressed in granulocyte stroma of bone marrow calvaria spermatid blood dermis secondary oocyte thymus islet of Langerhans right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase activity cytokine activity CCR5 chemokine receptor binding chemokine activity CCR1 chemokine receptor binding kinase activity phospholipase activator activity calcium-dependent protein kinase C activity protein binding identical protein binding chemoattractant activity CCR chemokine receptor binding Cellular component cytoplasm cytosol intracellular anatomical structure extracellular region extracellular space Biological process G protein-coupled receptor signaling pathway signaling negative regulation of bone mineralization positive regulation of protein kinase B signaling release of sequestered calcium ion into cytosol by sarcoplasmic reticulum response to cholesterol positive regulation of calcium-mediated signaling regulation of sensory perception of pain protein kinase B signaling monocyte chemotaxis negative regulation of osteoclast differentiation astrocyte cell migration positive regulation of cell migration positive regulation of natural killer cell chemotaxis chemokine-mediated signaling pathway T cell chemotaxis cell-cell signaling cellular response to tumor necrosis factor eosinophil chemotaxis cellular response to organic cyclic compound cellular calcium ion homeostasis negative regulation of gene expression neutrophil chemotaxis cell activation MAPK cascade chemotaxis positive regulation of GTPase activity positive regulation of neuron apoptotic process positive regulation of calcium ion import macrophage chemotaxis positive regulation of gene expression cytoskeleton organization osteoblast differentiation cellular response to interleukin-1 immune response positive regulation of ERK1 and ERK2 cascade regulation of cell shape positive regulation of tumor necrosis factor production cellular response to interferon-gamma lymphocyte chemotaxis inflammatory response granulocyte chemotaxis response to toxic substance eosinophil degranulation lipopolysaccharide-mediated signaling pathway calcium ion transport calcium-mediated signaling exocytosis positive regulation of calcium ion transport positive chemotaxis positive regulation of inflammatory response regulation of signaling receptor activity cytokine-mediated signaling pathway regulation of behavior positive regulation of microglial cell activation positive regulation of microglial cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6348 20302 Ensembl ENSG00000278567 ENSG00000277632 ENSG00000274221 ENSMUSG00000000982 UniProt P10147 P10855 RefSeq (mRNA) NM_002983 NM_011337 RefSeq (protein) NP_002974 NP_035467 Location (UCSC) Chr 17: 36.09 – 36.09 Mb Chr 11: 83.54 – 83.54 Mb PubMed search
Wikidata
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Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5.

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.

Interactions

CCL3 has been shown to interact with CCL4. Attracts macrophages, monocytes and neutrophils.

See also

• Macrophage inflammatory proteins

References

1. ^ ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000000982 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
6. Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
7. Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
8. Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. Bibcode:1989Sci...243.1066D. doi:10.1126/science.2646711. PMID 2646711.
9. Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

External links

• Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser.

Further reading

• Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
• Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
• Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
• Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
• Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.

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