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Interleukin 1 receptor, type I

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(Redirected from IL1R1) Type of interleukin receptor
IL1R1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1G0Y, 1IRA, 1ITB, 4DEP, 4GAF

Identifiers
AliasesIL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1
External IDsOMIM: 147810; MGI: 96545; HomoloGene: 677; GeneCards: IL1R1; OMA:IL1R1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)
Chromosome 2 (human)Genomic location for IL1R1Genomic location for IL1R1
Band2q11.2-q12.1Start102,064,544 bp
End102,179,874 bp
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)
Chromosome 1 (mouse)Genomic location for IL1R1Genomic location for IL1R1
Band1 B|1 18.81 cMStart40,225,080 bp
End40,317,257 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • palpebral conjunctiva

  • tibia

  • pericardium

  • corpus epididymis

  • decidua

  • caput epididymis

  • urethra

  • vena cava

  • visceral pleura

  • parietal pleura
Top expressed in
  • islet of Langerhans

  • seminal vesicula

  • umbilical cord

  • skin of external ear

  • medullary collecting duct

  • aortic valve

  • primary oocyte

  • ciliary body

  • tunica media of zone of aorta

  • cumulus cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3554

16177

Ensembl

ENSG00000115594

ENSMUSG00000026072

UniProt

P14778

P13504

RefSeq (mRNA)
NM_000877
NM_001288706
NM_001320978
NM_001320980
NM_001320981

NM_001320982
NM_001320983
NM_001320984
NM_001320985
NM_001320986

NM_001123382
NM_008362

RefSeq (protein)
NP_000868
NP_001275635
NP_001307907
NP_001307909
NP_001307910

NP_001307911
NP_001307912
NP_001307913
NP_001307914
NP_001307915

NP_001116854
NP_032388

Location (UCSC)Chr 2: 102.06 – 102.18 MbChr 1: 40.23 – 40.32 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP.

See also

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000115594Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000026072Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: IL1R1 interleukin 1 receptor, type I".
  6. Reddy, S A; Huang J H; Liao W S (November 1997). "Phosphatidylinositol 3-kinase in interleukin 1 signaling. Physical interaction with the interleukin 1 receptor and requirement in NFkappaB and AP-1 activation". J. Biol. Chem. 272 (46). UNITED STATES: 29167–73. doi:10.1074/jbc.272.46.29167. ISSN 0021-9258. PMID 9360994.
  7. Burns, K; Clatworthy J; Martin L; Martinon F; Plumpton C; Maschera B; Lewis A; Ray K; Tschopp J; Volpe F (June 2000). "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor". Nat. Cell Biol. 2 (6). ENGLAND: 346–51. doi:10.1038/35014038. ISSN 1465-7392. PMID 10854325. S2CID 32036101.
  8. Muzio, M; Ni J; Feng P; Dixit V M (November 1997). "IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling". Science. 278 (5343). UNITED STATES: 1612–5. Bibcode:1997Sci...278.1612M. doi:10.1126/science.278.5343.1612. ISSN 0036-8075. PMID 9374458.
  9. Huang, J; Gao X; Li S; Cao Z (November 1997). "Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (24). UNITED STATES: 12829–32. Bibcode:1997PNAS...9412829H. doi:10.1073/pnas.94.24.12829. ISSN 0027-8424. PMC 24223. PMID 9371760.

Further reading

PDB gallery
  • 1g0y: IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847 1g0y: IL-1 RECEPTOR TYPE 1 COMPLEXED WITH ANTAGONIST PEPTIDE AF10847
  • 1ira: COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA) 1ira: COMPLEX OF THE INTERLEUKIN-1 RECEPTOR WITH THE INTERLEUKIN-1 RECEPTOR ANTAGONIST (IL1RA)
  • 1itb: TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA 1itb: TYPE-1 INTERLEUKIN-1 RECEPTOR COMPLEXED WITH INTERLEUKIN-1 BETA

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50
51–100
101–150
151–200
201–250
251–300
301–350
Cytokine receptors
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamily
IL 17 family
Enzyme-linked receptor
Interleukin receptor modulators
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others
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