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NLRC3
Identifiers
Aliases	NLRC3, CLR16.2, NOD3, NLR family, CARD domain containing 3, NLR family CARD domain containing 3
External IDs	OMIM: 615648; MGI: 2444070; HomoloGene: 18720; GeneCards: NLRC3; OMA:NLRC3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p13.3 Start 3,539,033 bp End 3,577,403 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16|16 A1 Start 3,762,871 bp End 3,794,496 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus granulocyte mucosa of ileum blood lymph node endothelial cell spleen appendix epithelium of nasopharynx tonsil Top expressed in mesenteric lymph nodes blood thymus soleus muscle spleen lumbar subsegment of spinal cord stroma of bone marrow submandibular gland subcutaneous adipose tissue morula More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATP binding protein binding phosphatidylinositol 3-kinase regulatory subunit binding molecular function Cellular component cytoplasm microtubule organizing center cytosol perinuclear region of cytoplasm Biological process negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production I-kappaB kinase/NF-kappaB signaling negative regulation of NF-kappaB transcription factor activity T cell activation negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of phosphatidylinositol 3-kinase signaling negative regulation of interferon-alpha production negative regulation of interferon-beta production negative regulation of innate immune response negative regulation of fibroblast proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response negative regulation of cytokine production involved in inflammatory response negative regulation of NLRP3 inflammasome complex assembly negative regulation of NIK/NF-kappaB signaling intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 197358 268857 Ensembl ENSG00000167984 ENSMUSG00000049871 UniProt Q7RTR2 Q5DU56 RefSeq (mRNA) NM_178844 NM_001081280 NM_175547 RefSeq (protein) NP_849172 NP_001074749 NP_780756 Location (UCSC) Chr 16: 3.54 – 3.58 Mb Chr 16: 3.76 – 3.79 Mb PubMed search
Wikidata
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NLRC3, short for NOD-like receptor family CARD domain containing 3, is an intracellular protein that plays a role in the immune system. It was previously known as nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 (NOD3) and CLR16.2. NLRC3 inhibits the activity of T cells. NLRC3 also inhibits the mTOR signalling pathway to block cellular proliferation.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000167984 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000049871 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ting JP, Lovering RC, Alnemri ES, et al. (March 2008). "The NLR gene family: a standard nomenclature". Immunity. 28 (3): 285–7. doi:10.1016/j.immuni.2008.02.005. PMC 2630772. PMID 18341998.
6. Conti BJ, Davis BK, Zhang J, O'connor W, Williams KL, Ting JP (May 2005). "CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function". J. Biol. Chem. 280 (18): 18375–85. doi:10.1074/jbc.M413169200. PMID 15705585.
7. Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P (December 2016). "NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer". Nature. 540 (7634): 583–587. Bibcode:2016Natur.540..583K. doi:10.1038/nature20597. ISSN 1476-4687. PMC 5468516. PMID 27951586.

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• Genes on human chromosome 16
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