NLRP8 - Misplaced Pages

Protein-coding gene in the species Homo sapiens

NLRP8

Identifiers

NLRP8, CLR19.2, NALP8, NOD16, PAN4, NLR family, pyrin domain containing 8, NLR family pyrin domain containing 8

External IDs

OMIM: 609659; HomoloGene: 82360; GeneCards: NLRP8; OMA:NLRP8 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19q13.43	Start	55,947,832 bp
Band	19q13.43	End	55,988,629 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

testicle

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	nucleotide binding ATP binding molecular function
Cellular component	cytoplasm cellular component
Biological process	neuron death
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


126205


n/a

Ensembl


ENSG00000179709


n/a

UniProt


Q86W28


n/a

RefSeq (mRNA)


NM_176811 NM_001317000


n/a

RefSeq (protein)


NP_001303929 NP_789781


n/a

Location (UCSC)

Chr 19: 55.95 – 55.99 Mb

n/a

PubMed search

n/a

Wikidata

View/Edit Human

NLRP8, short for NOD-like receptor family pyrin domain containing 8, is an intracellular protein that is expressed in the ovaries, testes, and preimplantation embryos of mammals. It is also known as NALP8, NOD16, PAN4, and CLR19.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors.

References

^ GRCh38: Ensembl release 89: ENSG00000179709 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Ponsuksili S, Brunner RM, Goldammer T, et al. (March 2006). "Bovine NALP5, NALP8, and NALP9 genes: assignment to a QTL region and the expression in adult tissues, oocytes, and preimplantation embryos". Biol. Reprod. 74 (3): 577–84. doi:10.1095/biolreprod.105.045096. PMID 16339045. S2CID 2784688.
Tian X, Pascal G, Monget P (2009). "Evolution and functional divergence of NLRP genes in mammalian reproductive systems". BMC Evol. Biol. 9 (1): 202. Bibcode:2009BMCEE...9..202T. doi:10.1186/1471-2148-9-202. PMC 2735741. PMID 19682372.

Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
Tschopp J, Martinon F, Burns K (2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

v t e NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

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