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NLRP14
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4N1J, 4N1K, 4N1L
Identifiers
Aliases	NLRP14, CLR11.2, GC-LRR, NALP14, NOD5, PAN8, NLR family, pyrin domain containing 14, NLR family pyrin domain containing 14
External IDs	OMIM: 609665; MGI: 1924108; HomoloGene: 18531; GeneCards: NLRP14; OMA:NLRP14 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11p15.4 Start 7,020,479 bp End 7,071,526 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 E3 Start 106,766,197 bp End 106,797,309 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte testicle bone marrow cells ventricular zone olfactory zone of nasal mucosa ganglionic eminence liver human kidney spinal cord Top expressed in primary oocyte secondary oocyte zygote spermatid spermatocyte seminiferous tubule morula embryo ovary blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding nucleotide binding Cellular component cytoplasm Biological process cell differentiation multicellular organism development spermatogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 338323 76858 Ensembl ENSG00000158077 ENSMUSG00000016626 UniProt Q86W24 Q6B966 RefSeq (mRNA) NM_176822 NM_001002894 RefSeq (protein) NP_789792 NP_001002894 Location (UCSC) Chr 11: 7.02 – 7.07 Mb Chr 7: 106.77 – 106.8 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

NLRP14, short for NOD-like receptor family pyrin domain containing 14, is an intracellular protein of mammals associated with a role in spermatogenesis. It is also known as NALP14, NOD5, GC-LRR, Nalp-iota, PAN8, and CLR11.2, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors. NLRP14 is found exclusively in the testes where it is expressed within spermatogonia, spermatocytes and spermatids.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000158077 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000016626 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.
6. Westerveld GH, Korver CM, van Pelt AM, et al. (December 2006). "Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure". Hum. Reprod. 21 (12): 3178–84. doi:10.1093/humrep/del293. PMID 16931801.

Further reading

• Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia". Cancer Res. 68 (24): 10178–86. doi:10.1158/0008-5472.CAN-08-2221. PMID 19074885.
• Inohara N, Nuñez G (2003). "NODs: intracellular proteins involved in inflammation and apoptosis". Nat. Rev. Immunol. 3 (5): 371–82. doi:10.1038/nri1086. PMID 12766759. S2CID 8088987.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human NACHT, LRR and PYD domains-containing protein 14 (NLRP14)

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• Genes on human chromosome 11
• LRR proteins
• NOD-like receptors
• Transmembrane receptor stubs