Protein-coding gene in the species Homo sapiens
NLRP5 Identifiers Aliases NLRP5 , CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5External IDs OMIM : 609658 ; MGI : 1345193 ; HomoloGene : 65105 ; GeneCards : NLRP5 ; OMA :NLRP5 - orthologs Gene location (Mouse ) Chr. Chromosome 7 (mouse) Band 7 A3|7 10.22 cM Start 23,085,314 bp End 23,141,347 bp
Wikidata
NLRP5 , short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis . NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals .
In humans, the NLRP5 protein is encoded by the NLRP5 gene .
References
^ GRCh38: Ensembl release 89: ENSG00000171487 – Ensembl , May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000015721 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)" . Hum. Reprod . 24 (2): 415–24. doi :10.1093/humrep/den403 . PMID 19054779 .
Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells" . J. Reprod. Dev . 56 (1): 41–8. doi :10.1262/jrd.09-098a . PMID 19815987 .
"Entrez Gene: NLR family" .Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development" . Hum. Reprod . 17 (4): 903–11. doi :10.1093/humrep/17.4.903 . PMID 11925379 .
Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol . 4 (2): 95–104. doi :10.1038/nrm1019 . PMID 12563287 . S2CID 31417018 .
Further reading
Maraldi T, Riccio M, Sena P, et al. (2009). "MATER protein as substrate of PKCepsilon in human cumulus cells" . Mol. Hum. Reprod . 15 (8): 499–506. doi :10.1093/molehr/gap048 . PMID 19542546 . Enjuanes A, Benavente Y, Bosch F, et al. (2008). "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia" . Cancer Res . 68 (24): 10178–86. doi :10.1158/0008-5472.CAN-08-2221 . PMID 19074885 . Alimohammadi M, Björklund P, Hallgren A, et al. (2008). "Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen" . N. Engl. J. Med . 358 (10): 1018–28. doi :10.1056/NEJMoa0706487 . hdl :11577/2265363 . PMID 18322283 . S2CID 6542627 . Sena P, Riccio M, Marzona L, et al. (2009). "Human MATER localization in specific cell domains of oocytes and follicular cells" . Reprod. Biomed. Online . 18 (2): 226–34. doi :10.1016/s1472-6483(10)60260-x . PMID 19192343 .
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