Sovaprevir - Misplaced Pages

Chemical compound Pharmaceutical compound

Sovaprevir
Clinical data

Other names	ACH-1625
ATC code	None
Legal status
Legal status	Investigational
Identifiers
IUPAC name (4R)-N-{(1R,2S)-1--2-vinylcyclopropyl}-1-{(2S)-3,3-dimethyl-2-butanoyl}-4--L-prolinamide
CAS Number	1001667-23-7
PubChem CID	53362096
ChemSpider	28529313
UNII	2ND9V3MN6O
KEGG	D10166
ChEMBL	ChEMBL2105750
NIAID ChemDB	491583
CompTox Dashboard (EPA)	DTXSID00142994
Chemical and physical data
Formula	C₄₃H₅₃N₅O₈S
Molar mass	799.98 g·mol
3D model (JSmol)	Interactive image
SMILES CC(C)(C)(CC(=O)N1CCCCC1)C(=O)N2C(C2C(=O)N3(C3C=C)C(=O)NS(=O)(=O)C4CC4)OC5=CC(=NC6=C5C=CC(=C6)OC)C7=CC=CC=C7
InChI InChI=1S/C43H53N5O8S/c1-6-28-25-43(28,41(52)46-57(53,54)31-16-17-31)45-39(50)36-22-30(26-48(36)40(51)33(42(2,3)4)23-38(49)47-19-11-8-12-20-47)56-37-24-34(27-13-9-7-10-14-27)44-35-21-29(55-5)15-18-32(35)37/h6-7,9-10,13-15,18,21,24,28,30-31,33,36H,1,8,11-12,16-17,19-20,22-23,25-26H2,2-5H3,(H,45,50)(H,46,52)/t28-,30-,33-,36+,43-/m1/s1 Key:MHFMTUBUVQZIRE-WINRQGAFSA-N

Sovaprevir (codenamed ACH-1625) is an experimental drug designed to treat the hepatitis C virus. It is under development by Achillion Pharmaceuticals. It acts as a NS3/4A inhibitor. Sovaprevir received fast track status from the U.S. Food and Drug Administration in 2012.

References

De Clercq E (June 2014). "Current race in the development of DAAs (direct-acting antivirals) against HCV". Biochemical Pharmacology. 89 (4): 441–52. doi:10.1016/j.bcp.2014.04.005. PMID 24735613.
"Sovaprevir HCV NS3/4A Protease Inhibitor". Achillion.

NS3/4A protease inhibitors (–previr)	Asunaprevir Boceprevir Ciluprevir Danoprevir Faldaprevir Glecaprevir Grazoprevir Narlaprevir Paritaprevir Simeprevir Sovaprevir Telaprevir Vaniprevir Vedroprevir Voxilaprevir
NS5A inhibitors (–asvir)	Coblopasvir Daclatasvir Elbasvir Ledipasvir Odalasvir Ombitasvir Pibrentasvir Ravidasvir Ruzasvir Samatasvir Velpatasvir
NS5B RNA polymerase inhibitors (–buvir)	Beclabuvir Bemnifosbuvir Dasabuvir Deleobuvir Filibuvir GS-6620 IDX-184 Setrobuvir Sofosbuvir Tegobuvir TMC-647055 Radalbuvir Uprifosbuvir
Combination drugs	Elbasvir/grazoprevir Glecaprevir/pibrentasvir Ledipasvir/sofosbuvir Ombitasvir/paritaprevir/ritonavir Sofosbuvir/daclatasvir Sofosbuvir/velpatasvir Sofosbuvir/velpatasvir/voxilaprevir

Anti-influenza agents

Multiple/general

Interferon	Interferon alfa 2b Peginterferon alfa-2a Peginterferon alfa-2b
3CL protease inhibitors (–trelvir)	Ensitrelvir Ibuzatrelvir Lufotrelvir Nirmatrelvir (+ritonavir) Rupintrivir Simnotrelvir (+ritonavir)
RNA pol inhibitors	CMX521 Deuremidevir Favipiravir Galidesivir GS-441524 Remdesivir MK-608 Mericitabine Molnupiravir NITD008 Ribavirin Taribavirin Triazavirin Valopicitabine
Multiple/Unknown/Other	EICAR Merimepodib Moroxydine Presatovir

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