Protein-coding gene in the species Homo sapiens
Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene . The gem-associated proteins are those found in the gems of Cajal bodies .
Function
GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).
Interactions
Gem-associated protein 6 has been shown to interact with gem-associated protein 7 .
References
^ GRCh38: Ensembl release 89: ENSG00000152147 – Ensembl , May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000055760 – Ensembl , May 2017
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine ."Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component" . The Journal of Biological Chemistry . 277 (9): 7540–5. doi :10.1074/jbc.M110141200 . PMID 11748230 .
^ "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6" .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 .
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . The Journal of Biological Chemistry . 277 (35): 31957–62. doi :10.1074/jbc.M203478200 . PMID 12065586 .
Further reading
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex" . The Journal of Biological Chemistry . 277 (35): 31957–62. doi :10.1074/jbc.M203478200 . PMID 12065586 . Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure" . Structure . 13 (6): 883–92. doi :10.1016/j.str.2005.03.014 . PMID 15939020 . Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex" . The Journal of Biological Chemistry . 281 (48): 37009–16. doi :10.1074/jbc.M607505200 . PMID 17023415 . PDB gallery
1y96 : crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex
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