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On January 19, 2022, President Joe Biden nominated de Alba to serve as a United States district judge for the Eastern District of California. President Biden nominated her to the seat vacated by Judge Morrison C. England Jr., who assumed senior status on December 17, 2019. On April 27, 2022, a hearing on her nomination was held before the committee. On May 26, 2022, her nomination was favorably reported by the committee by a 12–10 vote. On June 13, 2022, Majority Leader Chuck Schumer filed cloture on her nomination. On June 16, 2022, the United States Senate invoked cloture on her nomination by a 52–43 vote. On June 21, 2022, her nomination was confirmed by a 53–45 vote. She received her judicial commission on July 7, 2022, and was sworn in on July 8, 2022. Her service was terminated on November 16, 2023, due to her elevation to the court of appeals.
Court of appeals
On April 14, 2023, President Biden announced his intent to nominate de Alba to serve as United States circuit judge for the Ninth Circuit. On April 17, 2023, her nomination was sent to the Senate. Biden nominated de Alba to the seat being vacated by Judge Paul J. Watford, who subsequently resigned on May 31, 2023. On May 17, 2023, a hearing on her nomination was held before the Senate Judiciary Committee. During her confirmation hearing, Republican senators criticized her over her sentencing record during her tenure as a district court judge, as well as pointing out her lack of knowledge of basic constitutional law, specifically with regards to the Dormant Commerce Clause. She was questioned over her sentencing of a man convicted of possession of child pornography. de Alba sentenced the man to 66-months in jail, which fell below the federal sentencing guideline of 78 to 97 months. In 2021, de Alba released from home monitoring an illegal immigrant tied to the killing of a police officer. On June 8, 2023, her nomination was reported out of committee by a party-line 11–10 vote. On November 9, 2023, the United States Senate invoked cloture on her nomination by a 49–42 vote, with Senator Joe Manchin voting against the motion to invoke cloture on her nomination. On November 13, 2023, her nomination was confirmed by a 48–43 vote, with Senator Manchin voting against confirmation. She received her judicial commission on November 15, 2023.