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Early in his career, Lohier worked as an associate in the law firm Cleary Gottlieb Steen & Hamilton. From 1997 to 2000, Lohier served as a Senior Trial Attorney with the United States Department of Justice Civil Rights Division, where he worked under Bill Lann Lee and spearheaded employment discrimination-related litigation and worked on other civil rights matters of importance to the federal government. He became an Assistant United States Attorney in 2000, and later became chief of the narcotics unit. He later became chief of the Securities and Commodities Fraud Task Force.
Lohier may be most known in his career at the U.S. Attorney's office for having helped to oversee the investigation into the Madoff investment scandal and worked as a prosecutor on the Marc Dreier case.
Federal judicial service
On February 8, 2010, Chuck Schumer announced that he would recommend Lohier for a seat on the United States Court of Appeals for the Second Circuit that was vacated by Sonia Sotomayor, who was elevated to the Supreme Court of the United States on August 6, 2009. On March 10, 2010, President Barack Obama nominated Lohier to the seat. On December 19, 2010, the Senate confirmed Lohier by a 92–0 vote. He received his judicial commission on December 20, 2010.
Personal
Lohier's wife, Donna Hae Kyun Lee, is Senior Associate Dean of Clinical Programs and a professor at the CUNY School of Law. The couple married in 1999 and lives in Brooklyn, New York In 2021, Lohier was elected to the Harvard Board of Overseers for a six-year term ending in 2027. Lohier is also an elected member of the American Law Institute.