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In the 2002 midterm congressional elections, the Republicans regained control of the Senate. During the new 108th Congress, Senator Orrin Hatch, R-UT, the new Republican chairman of the Senate Judiciary Committee began to process the previously blocked four nominees. In March 2003, Michigan's two Democratic senators, Carl Levin (who defeated Griffin's father, Robert P. Griffin, in his bid for re-election in 1978) and Debbie Stabenow announced that they would blue-slip all Bush judicial nominees from Michigan because Bush refused to renominate Helene White and Kathleen McCree Lewis, two Michigan nominees to the Sixth Circuit whose nominations the Senate Republicans had refused to process during President Bill Clinton's second term. Helene White at the time was married to Levin's cousin.
Contrary to Levin's and Stabenow's wishes, Hatch gave Saad, McKeague and Griffin committee hearings, and passed the three nominees out of committee. Furious, Levin and Stabenow convinced their caucus to filibuster the three in order to prevent them from having confirmation votes.
Senate Republicans increased their numbers in the 109th Congress. Tensions between the Republicans and Democrats rose dramatically as the Republicans, unable to end debate through cloture, considered breaking the filibusters of ten Bush court of appeals nominees (including Saad, McKeague and Griffin) by using the nuclear option. In order to defuse the volatile situation, fourteen moderate Republican and Democratic senators called the Gang of 14 joined together to forge an agreement to guarantee certain filibustered nominations up or down votes. Henry Saad and William Myers, however, were expressly excluded from the deal.
As part of the Gang of 14 Deal, Griffin was eventually confirmed on June 9, 2005 by a 95–0 vote. In the end, both Levin and Stabenow voted in favor of his confirmation. McKeague was confirmed on the same day. He received his commission on June 10, 2005.