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Loken served as chief judge of the court from April 1, 2003, to March 31, 2010, when he was succeeded by William J. Riley. He has been the oldest Eighth Circuit judge who still occupies their seat (meaning not in senior status) since December 14, 2018, when Roger Leland Wollman went senior.
In November 2022, Loken wrote for a three-judge panel upholding an immigration judge's finding that an asylum applicant who had been brutally raped by military officers in her home country, Cameroon, was not credible because she did not provide medical records from the government hospital that attended to her injuries.