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KIF4A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3ZFC, 6OYL, 3ZFD
Identifiers
Aliases	KIF4A, KIF4, KIF4G1, MRX100, kinesin family member 4A, XLID100
External IDs	OMIM: 300521; MGI: 108389; HomoloGene: 69022; GeneCards: KIF4A; OMA:KIF4A - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq13.1 Start 70,290,104 bp End 70,420,886 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X C3|X 43.72 cM Start 99,669,343 bp End 99,770,820 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte ventricular zone ganglionic eminence gonad testicle bone marrow trabecular bone stromal cell of endometrium mucosa of transverse colon Top expressed in zygote primary oocyte otic placode genital tubercle otic vesicle secondary oocyte tail of embryo saccule ventricular zone fetal liver hematopoietic progenitor cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding microtubule motor activity nucleotide binding microtubule binding protein binding ATP binding plus-end-directed microtubule motor activity ATPase activity Cellular component cytosol membrane kinesin complex nuclear matrix spindle nucleoplasm chromosome spindle microtubule microtubule cytoskeleton nucleus axon cytoplasm midbody cytoplasm intercellular bridge Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle midzone assembly mitotic cytokinesis organelle organization anterograde axonal transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement mitotic spindle organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24137 16571 Ensembl ENSG00000090889 ENSMUSG00000034311 UniProt O95239 P33174 RefSeq (mRNA) NM_012310 NM_008446 RefSeq (protein) NP_036442 NP_032472 Location (UCSC) Chr X: 70.29 – 70.42 Mb Chr X: 99.67 – 99.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.

Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.

Interactions

KIF4A has been shown to interact with HMG20B and DNMT3B.

Clinical significance

NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV). KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–42. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.
6. ^ "Entrez Gene: KIF4A kinesin family member 4A".
7. Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
8. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
9. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife. 1: e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.
10. Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro". PLOS Pathogens. 18 (3): e1009983. doi:10.1371/journal.ppat.1009983. PMC 8970526. PMID 35312737.

Further reading

• Sekine Y, Okada Y, Noda Y, Kondo S, Aizawa H, Takemura R, Hirokawa N (October 1994). "A novel microtubule-based motor protein (KIF4) for organelle transports, whose expression is regulated developmentally". The Journal of Cell Biology. 127 (1): 187–201. doi:10.1083/jcb.127.1.187. PMC 2120182. PMID 7929562.
• Yan RT, Wang SZ (April 1997). "Increased chromokinesin immunoreactivity in retinoblastoma cells". Gene. 189 (2): 263–267. doi:10.1016/S0378-1119(96)00860-8. PMID 9168136.
• Tang Y, Winkler U, Freed EO, Torrey TA, Kim W, Li H, et al. (December 1999). "Cellular motor protein KIF-4 associates with retroviral Gag". Journal of Virology. 73 (12): 10508–10513. doi:10.1128/JVI.73.12.10508-10513.1999. PMC 113106. PMID 10559369.
• Oh S, Hahn H, Torrey TA, Shin H, Choi W, Lee YM, et al. (September 2000). "Identification of the human homologue of mouse KIF4, a kinesin superfamily motor protein". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (1–2): 219–224. doi:10.1016/s0167-4781(00)00151-2. PMID 10978527.
• Lee YM, Lee S, Lee E, Shin H, Hahn H, Choi W, Kim W (December 2001). "Human kinesin superfamily member 4 is dominantly localized in the nuclear matrix and is associated with chromosomes during mitosis". The Biochemical Journal. 360 (Pt 3): 549–556. doi:10.1042/0264-6021:3600549. PMC 1222256. PMID 11736643.
• Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
• Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
• Lee YM, Kim W (February 2004). "Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells". Experimental & Molecular Medicine. 36 (1): 93–97. doi:10.1038/emm.2004.13. PMID 15031677.
• Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
• Kurasawa Y, Earnshaw WC, Mochizuki Y, Dohmae N, Todokoro K (August 2004). "Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation". The EMBO Journal. 23 (16): 3237–3248. doi:10.1038/sj.emboj.7600347. PMC 514520. PMID 15297875.
• Mazumdar M, Sundareshan S, Misteli T (August 2004). "Human chromokinesin KIF4A functions in chromosome condensation and segregation". The Journal of Cell Biology. 166 (5): 613–620. doi:10.1083/jcb.200401142. PMC 2172419. PMID 15326200.
• Zhu C, Jiang W (January 2005). "Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis". Proceedings of the National Academy of Sciences of the United States of America. 102 (2): 343–348. Bibcode:2005PNAS..102..343Z. doi:10.1073/pnas.0408438102. PMC 544298. PMID 15625105.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

External links

• "KIF4A Foundation".

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