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MYL6
Identifiers
Aliases	MYL6, ESMLC, LC17, LC17-GI, LC17-NM, LC17A, LC17B, MLC-3, MLC1SM, MLC3NM, MLC3SM, myosin light chain 6
External IDs	OMIM: 609931; MGI: 109318; HomoloGene: 69080; GeneCards: MYL6; OMA:MYL6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.2 Start 56,158,346 bp End 56,163,496 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D3 Start 128,326,729 bp End 128,330,014 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle layer of sigmoid colon popliteal artery tibial arteries left coronary artery right coronary artery ascending aorta Descending thoracic aorta mucosa of transverse colon gastric mucosa body of uterus Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell right kidney lip superior frontal gyrus yolk sac neural layer of retina ventricular zone primary visual cortex spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding structural constituent of muscle cytoskeletal motor activity protein binding Cellular component vesicle cytosol unconventional myosin complex extracellular exosome membrane brush border myosin complex extracellular matrix Biological process muscle contraction skeletal muscle tissue development muscle filament sliding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4637 17904 Ensembl ENSG00000092841 ENSMUSG00000090841 UniProt P60660 Q60605 RefSeq (mRNA) NM_079425 NM_021019 NM_079423 NM_010860 NM_001317217 NM_001317218 NM_001317219 NM_001317220 RefSeq (protein) NP_066299 NP_524147 NP_001304146 NP_001304147 NP_001304148 NP_001304149 NP_034990 Location (UCSC) Chr 12: 56.16 – 56.16 Mb Chr 10: 128.33 – 128.33 Mb PubMed search
Wikidata
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Myosin light polypeptide 6 is a protein that in humans is encoded by the MYL6 gene.

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000092841 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000090841 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bora PS, Bora NS, Wu X, Kaplan HJ, Lange LG (Jun 1994). "Molecular cloning, sequencing, and characterization of smooth muscle myosin alkali light chain from human eye cDNA: homology with myocardial fatty acid ethyl ester synthase-III cDNA". Genomics. 19 (1): 186–8. doi:10.1006/geno.1994.1041. PMID 8188229.
6. Hailstones DL, Gunning PW (Mar 1990). "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function". Mol Cell Biol. 10 (3): 1095–104. doi:10.1128/mcb.10.3.1095. PMC 360973. PMID 2304459.
7. Lenz S, Lohse P, Seidel U, Arnold HH (Jun 1989). "The alkali light chains of human smooth and nonmuscle myosins are encoded by a single gene. Tissue-specific expression by alternative splicing pathways". J Biol Chem. 264 (15): 9009–15. doi:10.1016/S0021-9258(18)81895-6. PMID 2722814.
8. ^ "Entrez Gene: MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle".

Further reading

• Komiyama M, Soldati T, von Arx P, Perriard JC (1997). "The intracompartmental sorting of myosin alkali light chain isoproteins reflects the sequence of developmental expression as determined by double epitope-tagging competition". J. Cell Sci. 109 (8): 2089–99. doi:10.1242/jcs.109.8.2089. PMID 8856505.
• Watanabe M, Kohri M, Takaishi M, et al. (2001). "Molecular cloning and sequencing of myosin light chains in human megakaryoblastic leukemia cells". Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 37 (1): 25–38. doi:10.1540/jsmr.37.25. PMID 11436981.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Fu ZY, Xie BT, Ma YT, Gong ZX (2006). "Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies". Acta Biochim. Biophys. Sin. (Shanghai). 38 (9): 625–32. doi:10.1111/j.1745-7270.2006.00203.x. PMID 16953301. S2CID 15419702.

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