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TMOD3
Identifiers
Aliases	TMOD3, UTMOD, tropomodulin 3
External IDs	OMIM: 605112; MGI: 1355315; HomoloGene: 8727; GeneCards: TMOD3; OMA:TMOD3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.2 Start 51,829,628 bp End 51,947,295 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 42.3 cM Start 75,404,989 bp End 75,466,939 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in amniotic fluid oral cavity buccal mucosa cell gums lower lobe of lung gingival epithelium epithelium of colon skin of hip Achilles tendon mucosa of sigmoid colon Top expressed in lactiferous gland Ileal epithelium corneal stroma left lung lobe sciatic nerve cardiac muscle tissue of left ventricle seminal vesicula right lung lobe blood genital tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function actin binding cadherin binding involved in cell-cell adhesion tropomyosin binding Cellular component cytoplasm cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping positive regulation of mitotic cell cycle phase transition actin cytoskeleton organization erythrocyte development cell-cell adhesion muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29766 50875 Ensembl ENSG00000138594 ENSMUSG00000058587 UniProt Q9NYL9 Q9JHJ0 RefSeq (mRNA) NM_014547 NM_016963 NM_001357828 RefSeq (protein) NP_055362 NP_058659 NP_001344757 Location (UCSC) Chr 15: 51.83 – 51.95 Mb Chr 9: 75.4 – 75.47 Mb PubMed search
Wikidata
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Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000138594 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000058587 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fischer, Robert S.; Yarmola, Elena G.; Weber, Kari L.; Speicher, Kaye D.; Speicher, David W.; Bubb, Michael R.; Fowler, Velia M. (2006-11-24). "Tropomodulin 3 Binds to Actin Monomers". Journal of Biological Chemistry. 281 (47): 36454–36465. doi:10.1074/jbc.M606315200. ISSN 0021-9258. PMID 17012745.
6. "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility (PDF Download Available)". ResearchGate. Retrieved 2017-03-28.
7. Cox PR, Zoghbi HY (Apr 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
8. "Entrez Gene: TMOD3 tropomodulin 3 (ubiquitous)".

Further reading

• Weber KL, Fischer RS, Fowler VM (2008). "Tmod3 regulates polarized epithelial cell morphology". J. Cell Sci. 120 (Pt 20): 3625–32. doi:10.1242/jcs.011445. PMID 17928307.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Fischer RS, Yarmola EG, Weber KL, et al. (2007). "Tropomodulin 3 binds to actin monomers". J. Biol. Chem. 281 (47): 36454–65. doi:10.1074/jbc.M606315200. PMID 17012745.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Fischer RS, Fritz-Six KL, Fowler VM (2003). "Pointed-end capping by tropomodulin3 negatively regulates endothelial cell motility". J. Cell Biol. 161 (2): 371–80. doi:10.1083/jcb.200209057. PMC 2172920. PMID 12707310.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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