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KRT23
Identifiers
Aliases	KRT23, CK23, HAIK1, K23, keratin 23
External IDs	OMIM: 606194; MGI: 2148866; HomoloGene: 9172; GeneCards: KRT23; OMA:KRT23 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 40,922,700 bp End 40,937,646 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 D Start 99,368,800 bp End 99,383,963 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta skin of leg skin of abdomen olfactory zone of nasal mucosa salivary gland minor salivary glands blood islet of Langerhans tonsil right uterine tube Top expressed in otic placode esophagus epithelium of stomach lip submandibular gland skin of back saccule parotid gland mucous cell of stomach otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity Cellular component intermediate filament cytosol Biological process keratinization cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25984 94179 Ensembl ENSG00000108244 ENSG00000263309 ENSMUSG00000006777 UniProt Q9C075 Q99PS0 RefSeq (mRNA) NM_001282433 NM_015515 NM_173213 NM_033373 RefSeq (protein) NP_001269362 NP_056330 NP_203537 Location (UCSC) Chr 17: 40.92 – 40.94 Mb Chr 11: 99.37 – 99.38 Mb PubMed search
Wikidata
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Keratin, type I cytoskeletal 23 is a protein that in humans is encoded by the KRT23 gene.

The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratin and hair keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21.

References

1. ^ ENSG00000263309 GRCh38: Ensembl release 89: ENSG00000108244, ENSG00000263309 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000006777 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Zhang JS, Wang L, Huang H, Nelson M, Smith DI (Jan 2001). "Keratin 23 (K23), a novel acidic keratin, is highly induced by histone deacetylase inhibitors during differentiation of pancreatic cancer cells". Genes Chromosomes Cancer. 30 (2): 123–35. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1070>3.0.CO;2-W. PMID 11135429. S2CID 40237049.
6. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
7. ^ "KRT23 keratin 23 [ Homo sapiens (human) ]".

Further reading

• Suzuki A, Ji G, Numabe Y, et al. (2004). "Single nucleotide polymorphisms associated with aggressive periodontitis and severe chronic periodontitis in Japanese". Biochem. Biophys. Res. Commun. 317 (3): 887–92. doi:10.1016/j.bbrc.2004.03.126. PMID 15081423.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tolstonog GV, Sabasch M, Traub P (2002). "Cytoplasmic intermediate filaments are stably associated with nuclear matrices and potentially modulate their DNA-binding function". DNA Cell Biol. 21 (3): 213–39. doi:10.1089/10445490252925459. PMID 12015898.
• Hesse M, Magin TM, Weber K (2002). "Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18". J. Cell Sci. 114 (Pt 14): 2569–75. doi:10.1242/jcs.114.14.2569. PMID 11683385.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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