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TMOD4
Identifiers
Aliases	TMOD4, SK-TMOD, tropomodulin 4
External IDs	OMIM: 605834; MGI: 1355285; HomoloGene: 8355; GeneCards: TMOD4; OMA:TMOD4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 151,169,986 bp End 151,176,284 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F2.1|3 40.74 cM Start 95,031,787 bp End 95,036,520 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vastus lateralis muscle Skeletal muscle tissue of rectus abdominis tibialis anterior muscle biceps brachii muscle of thigh gastrocnemius muscle Skeletal muscle tissue of biceps brachii deltoid muscle body of tongue granulocyte Top expressed in triceps brachii muscle sternocleidomastoid muscle medial head of gastrocnemius muscle temporal muscle quadriceps femoris muscle tibialis anterior muscle vastus lateralis muscle skeletal muscle tissue muscle of thigh digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function actin filament binding actin binding tropomyosin binding Cellular component cytoplasm cytoskeleton striated muscle thin filament myofibril Biological process pointed-end actin filament capping muscle contraction actin filament organization myofibril assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29765 50874 Ensembl ENSG00000163157 ENSMUSG00000005628 UniProt Q9NZQ9 Q9JLH8 RefSeq (mRNA) NM_013353 NM_016712 RefSeq (protein) NP_037485 NP_057921 Location (UCSC) Chr 1: 151.17 – 151.18 Mb Chr 3: 95.03 – 95.04 Mb PubMed search
Wikidata
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Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.

Function

This gene encodes a muscle-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000163157 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000005628 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
6. Almenar-Queralt A, Lee A, Conley CA, Ribas de Pouplana L, Fowler VM (October 1999). "Identification of a novel tropomodulin isoform, skeletal tropomodulin, that caps actin filament pointed ends in fast skeletal muscle". J. Biol. Chem. 274 (40): 28466–75. doi:10.1074/jbc.274.40.28466. PMID 10497209.
7. "Entrez Gene: TMOD4, Tropomodulin 4 (muscle)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cox PR, Siddique T, Zoghbi HY (2001). "Genomic organization of Tropomodulins 2 and 4 and unusual intergenic and intraexonic splicing of YL-1 and Tropomodulin 4". BMC Genomics. 2: 7. doi:10.1186/1471-2164-2-7. PMC 59888. PMID 11716785.
• McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi:10.1074/jbc.M005693200. PMID 11016930.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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