Misplaced Pages

Aglepristone

Clinical data
Trade names	Alizin
Other names	RU-46534; RU-534; 11β--17β-hydroxy-17α-estra-4,9-dien-3-one
Drug class	Antiprogestogen; Antiglucocorticoid
ATC code	G03XB90 (WHO)
Identifiers
IUPAC name (8S,11R,13S,14S,17R)-11--17-hydroxy-13-methyl-17--1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaphenanthren-3-one
CAS Number	124478-60-0
PubChem CID	14153279
ChemSpider	16736563
UNII	0UT4JLE1CM
KEGG	D07096
ChEMBL	ChEMBL2103998
CompTox Dashboard (EPA)	DTXSID001016632
ECHA InfoCard	100.211.372
Chemical and physical data
Formula	C29H37NO2
Molar mass	431.620 g·mol
3D model (JSmol)	Interactive image
SMILES C/C=C\1(CC21(C(C3=C4CCC(=O)C=C4CC23)C5=CC=C(C=C5)N(C)C)C)O
InChI InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1 Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N

Aglepristone (INNTooltip International Nonproprietary Name) (brand name Alizin; former developmental code names RU-46534, RU-534) is a synthetic, steroidal antiprogestogen related to mifepristone which is marketed by Virbac in several European countries for use in veterinary medicine. It is specifically used as an abortifacient in pregnant animals. Aglepristone, similarly to mifepristone, also possesses some antiglucocorticoid activity.

See also

• Lilopristone
• Onapristone
• Telapristone
• Toripristone

References

1. ^ Kaufman LK, Baldwin CJ (1 December 2013). "Pregnancy Loss in the Bitch and Queen". In Bonagura JD, Twedt DC (eds.). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. pp. 3009–. ISBN 978-0-323-22762-9.
2. Squires EJ (2010). "Endocrine manipulation of reproduction.". Applied Animal Endocrinology. CABI. pp. 207–. ISBN 978-1-84593-755-3.
3. ^ Papich MC (3 November 2010). "Aglepristone". Saunders Handbook of Veterinary Drugs: Small and Large Animal. Elsevier Health Sciences. pp. 120–. ISBN 978-1-4377-0192-0.
4. Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001). Concannon PW (ed.). "Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)". Journal of Reproduction and Fertility. Supplement. Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000. 57: 243–8. ISBN 978-0-906545-37-9. PMID 11787157.
5. Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat". Reproduction in Domestic Animals = Zuchthygiene. 46 (5): 882–888. doi:10.1111/j.1439-0531.2011.01759.x. PMID 21320179.
6. Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs". Theriogenology. 69 (4): 399–407. doi:10.1016/j.theriogenology.2007.10.008. PMID 18054071.

This drug article relating to the genito-urinary system is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

This article about a steroid is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Abortifacients
• Alkene derivatives
• Dimethylamino compounds
• Antiglucocorticoids
• Antiprogestogens
• Estranes
• Enones
• Theriogenology
• Veterinary drugs
• Genito-urinary system drug stubs
• Steroid stubs