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Clobetasol

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Chemical compound Not to be confused with Clobetasol propionate. Pharmaceutical compound
Clobetasol
Clinical data
Other names9α-Fluoro-11β,17α-dihydroxy-16β-methyl-21-chloropregna-1,4-diene-3,20-dione
Pregnancy
category
  • AU: B3
Drug classCorticosteroid; Glucocorticoid
ATC code
  • None
Identifiers
IUPAC name
  • (8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopentaphenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.042.379 Edit this at Wikidata
Chemical and physical data
FormulaC22H28ClFO4
Molar mass410.91 g·mol
3D model (JSmol)
SMILES
  • C1C23CCC4=CC(=O)C=C4(3((C2(1(C(=O)CCl)O)C)O)F)C
InChI
  • InChI=1S/C22H28ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,17-,19-,20-,21-,22-/m0/s1
  • Key:FCSHDIVRCWTZOX-DVTGEIKXSA-N

Clobetasol is a synthetic glucocorticoid corticosteroid. A propionate ester of clobetasol, clobetasol propionate, has also been marketed, and is far more widely used in comparison.

References

  1. "Updates to the Prescribing Medicines in Pregnancy database". Therapeutic Goods Administration (TGA). 21 December 2022. Archived from the original on 3 April 2022. Retrieved 2 January 2023.
  2. Elks J, Ganellin CR, eds. (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 292–. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2085-3.
  3. Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 252–. ISBN 978-3-88763-075-1.
Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
Natural
Synthetic
Antiglucocorticoids
Synthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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