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Domoprednate

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Chemical compound Pharmaceutical compound
Domoprednate
Clinical data
Trade namesStermonid
Other namesRo 12-7024; 11β-Hydroxy-D-homopregna-1,4-diene-3,20-dione 17α-butyrate
Routes of
administration		Topical
Drug classCorticosteroid; Glucocorticoid
Identifiers
IUPAC name
  • butanoate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.060.441 Edit this at Wikidata
Chemical and physical data
FormulaC26H36O5
Molar mass428.569 g·mol
3D model (JSmol)
SMILES
  • CCCC(=O)O1(CCC21(C(32CCC4=CC(=O)C=C34C)O)C)C(=O)C
InChI
  • InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1
  • Key:IYBYNRHXGXDDDS-VRRJBYJJSA-N

Domoprednate (brand name Stermonid; developmental code name Ro 12-7024) is a synthetic glucocorticoid corticosteroid which was developed in the late 1970s and 1980s.

References

  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 465–. ISBN 978-1-4757-2085-3.
  2. Schmidt H, Hjorth N, Holm P (1984). "A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses". Dermatologica. 168 (3): 127–30. doi:10.1159/000249683. PMID 6370748.
  3. Serup J, Holm P (1985). "Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo". Dermatologica. 170 (4): 189–94. doi:10.1159/000249529. PMID 3888708.
  4. Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F (1985). "The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial". Dermatologica. 170 (4): 195–8. doi:10.1159/000249530. PMID 3888709.
  5. Schmidt H, Hjorth N, Holm P (1987). "Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate". Dermatologica. 175 (3): 145–7. doi:10.1159/000248813. PMID 3653463.


Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
Natural
Synthetic
Antiglucocorticoids
Synthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
Agonists
Mixed
(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
Others
See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids
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