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Tixocortol pivalate

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Tixocortol pivalate
Names
IUPAC name S-(11β,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl) 2,2-dimethylpropanethioate
Systematic IUPAC name S-{2-phenanthren-1-yl]-2-oxoethyl} 2,2-dimethylpropanethioate
Identifiers
CAS Number
3D model (JSmol)
ECHA InfoCard 100.054.261 Edit this at Wikidata
PubChem CID
UNII
CompTox Dashboard (EPA)
SMILES
  • CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CSC(=O)C(C)(C)C)O)C)O
Properties
Chemical formula C26H38O5S
Molar mass 462.64
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒verify (what is  ?) Infobox references
Chemical compound

Tixocortol pivalate is a corticosteroid. It has anti-inflammatory properties similar to hydrocortisone. It is marketed under the brand name Pivalone.

It is sometimes used in patch testing in atopic dermatitis.

See also

References

  1. P Larochelle MD, PhD; P Du Souich MD, PhD; E Bolte MD; J Lelorier MD, PhD & R Goyer PhD (1983). "Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application". Clinical Pharmacology and Therapeutics. 33 (3): 343–350. doi:10.1038/clpt.1983.43. PMID 6402333. S2CID 29876079. Retrieved 2011-03-29.
  2. "Tixocortol Pivalate". Drugs.com. Retrieved 2011-03-29.
  3. Nedorost ST, Babineau D (October 2010). "Patch testing in atopic dermatitis". Dermatitis. 21 (5): 251–4. doi:10.2310/6620.2010.10036. PMID 20920410. S2CID 25026888.
Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
Natural
Synthetic
Antiglucocorticoids
Synthesis modifiers
See also
Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
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See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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