Diflorasone diacetate - Misplaced Pages

Chemical compound and topical steroid Pharmaceutical compound

Diflorasone diacetate
Clinical data

Trade names	Psorcon
AHFS/Drugs.com	Monograph
MedlinePlus	a602019
License data	US DailyMed: Diflorasone
Routes of administration	Topical
ATC code	D07AC10 (WHO)
Legal status
Legal status	US: ℞-only
Identifiers
IUPAC name phenanthren-17-yl] acetate
CAS Number	2557-49-5
PubChem CID	71414
IUPHAR/BPS	7068
DrugBank	DB00223
ChemSpider	64504
UNII	T2DHJ9645W
KEGG	D01327
ChEBI	CHEBI:31483
ChEMBL	ChEMBL1201380
CompTox Dashboard (EPA)	DTXSID8045646
ECHA InfoCard	100.046.872
Chemical and physical data
Formula	C₂₆H₃₂F₂O₇
Molar mass	494.532 g·mol
InChI InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N
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Diflorasone diacetate is a topical steroid that comes in the form of a cream. It is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I corticosteroid in the United States.

No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.

Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to an infant.

References

Shupack JL, Jondreau L, Kenny C, Stiller MJ (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–32. doi:10.1159/000247323. PMID 8428041.
"Topical Steroids Potency Chart". psoriasis.org.
"Diflorasone topical". Drugs.com.

External links

"Diflorasone diacetate". Drug Information Portal. U.S. National Library of Medicine.

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Medicine

Glucocorticoids and antiglucocorticoids (D07, H02)

Glucocorticoids

Natural

Synthetic

Cortisol-like and related (16-unsubstituted): Chloroprednisone
Cloprednol
Difluprednate
Fludrocortisone
Flugestone acetate (flurogestone acetate)
Fluocinolone
Fluorometholone
- Fluorometholone acetate
Fluperolone
- Fluperolone acetate
Fluprednisolone
- Fluprednisolone esters
Loteprednol (+tobramycin)
Medrysone
Methylprednisolone
- Methylprednisolone esters
Methylprednisolone aceponate
Prednicarbate
Prednisolone
Prednisone
Tixocortol
- Tixocortol pivalate

Methasones and related (16-substituted): Alclometasone
Beclometasone
- Beclometasone esters
Betamethasone
- Betamethasone esters
Clobetasol
- Clobetasol propionate
Clobetasone
Clocortolone
- Clocortolone esters
Cortivazol
Desoximetasone
Dexamethasone
- Dexamethasone esters
Diflorasone
Diflucortolone
- Diflucortolone valerate
Fluclorolone
Flumetasone
Fluocortin
Fluocortolone
- Fluocortolone esters
Fluprednidene acetate
Fluticasone
- Fluticasone furoate
- Fluticasone propionate
Halometasone
Meprednisone
Mometasone
- Mometasone furoate
Paramethasone
Prednylidene
Rimexolone
Triamcinolone
Ulobetasol (halobetasol)

Cyclic ketals (16,17-cyclized): Amcinonide
Budesonide
Ciclesonide
Deflazacort
Desonide
Fluclorolone acetonide (flucloronide)
Fludroxycortide (flurandrenolone, flurandrenolide)
Flunisolide
Fluocinolone acetonide
Fluocinonide
Formocortal (fluoroformylone)
Halcinonide
Triamcinolone acetonide
- Triamcinolone acetonide esters

Antiglucocorticoids

Synthesis modifiers

WHO-EM
Withdrawn from market
Clinical trials:
- Phase III
- Never to phase III

See also: Glucocorticoid receptor modulators; Mineralocorticoids and antimineralocorticoids; List of corticosteroids

Glucocorticoid receptor modulators

GRTooltip Glucocorticoid receptor

Agonists	Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone 5α-Dihydrocorticosterone 9α-Fluorocortisone (alfluorone) 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone) 11-Dehydrocorticosterone acetate 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone) Desoxycortone esters 11-Deoxycortisol (cortodoxone, cortexolone) Cortifen (cortiphen, kortifen) Cortodoxone acetate 21-Deoxycortisol Δ-Prednisolone Δ-Prednisolone 21-acetate Amebucort Chloroprednisone Chloroprednisone acetate Cloprednol Cloprednol acetate Corticosterone Corticosterone acetate Corticosterone benzoate Cortisol (hydrocortisone) Benzodrocortisone (hydrocortisone benzoate) Hydrocortamate (hydrocortisone diethylaminoacetate) Hydrocortisone esters Cortisone Cortisone acetate Deprodone Deprodone propionate Dichlorisone Dichlorisone acetate Dichlorisone diacetate Difluprednate Endrisone (endrysone) Etiprednol Etiprednol dicloacetate (etiprednol dichloroacetate) Fludrocortisone (fludrocortone) Fludrocortisone acetate Fluorometholone Fluorometholone acetate Fluperolone Fluperolone acetate Fluprednisolone Fluprednisolone esters Halopredone Halopredone acetate (halopredone diacetate) Isoflupredone (9α-fluoroprednisolone) Isoflupredone acetate Loteprednol Mazipredone (depersolone) Medrysone Methylprednisolone Methylprednisolone esters Prebediolone Prebediolone acetate Prednisolone Prednazate Prednazoline Prednicarbate (prednisolone ethylcarbonate propionate) Prednimustine Prednisolamate (prednisolone diethylaminoacetate) Prednisolone esters Prednisone Prednisone esters Pregnenolone Pregnenolone acetate Pregnenolone succinate (pregnenolone hemisuccinate) Resocortol Tipredane Tixocortol Butixocort (tixocortol butyrate) Butixocort propionate Tixocortol pivalate Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone Alclometasone Alclometasone dipropionate Amelometasone Beclometasone (beclomethasone) Beclometasone esters Betamethasone (betametasone) Betamethasone esters Cortobenzolone (betamethasone salicylate) Ciclometasone (ciclomethasone, cyclomethasone) Clobetasol Clobetasol propionate Clobetasone Clobetasone butyrate Clocortolone Clocortolone esters Cloticasone Cloticasone propionate Cormetasone (cormethasone) Cormetasone acetate Descinolone Desoximetasone (desoxymethasone) Dexamethasone (dexametasone) Dexamethasone esters Diflorasone Diflorasone diacetate Diflucortolone Diflucortolone pivalate Diflucortolone valerate Dimesone Dimesone acetate Doxibetasol (doxybetasol) Fluclorolone Flumetasone (flumethasone) Flumetasone acetate Flumetasone pivalate Fluocinolone Fluocortin Fluocortin butyl (fluocortin butylate) Fluocortolone Fluocortolone esters Fluprednidene (fluprednylidene) Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halocortolone Halometasone Icometasone Icometasone enbutate (icometasone butyrate acetate) Isoprednidene Locicortolone (locicortone) Locicortolone dicibate (locicortone dicibate) Meclorisone Meclorisone dibutyrate Meprednisone (methylprednisone) Meprednisone acetate Meprednisone hydrogen succinate (methylprednisone hemisuccinate) Mometasone Mometasone furoate Paramethasone Paramethasone acetate Paramethasone disodium phosphate Paramethasone phosphate Prednylidene Prednylidene diethylaminoacetate Rimexolone Ticabesone Ticabesone propionate Timobesone Timobesone acetate Triamcinolone Triamcinolone diacetate Ulobetasol (halobetasol) Ulobetasol propionate Vamorolone Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide) Amcinafal (triamcinolone pentanonide) Amcinafide (triamcinolone acetophenide) Amcinonide (triamcinolone acetate cyclopentanonide) Budesonide Ciclesonide Cicortonide Deflazacort (azacort) Descinolone acetonide Desonide (hydroxyprednisolone acetonide) Desonide disodium phosphate Desonide pivalate Dexbudesonide Drocinonide Drocinonide phosphate Fluazacort Fluclorolone acetonide (flucloronide) Fludroxycortide (flurandrenolone, flurandrenolide) Flumoxonide Flunisolide Flunisolide acetate Fluocinolone acetonide Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate) Fluocinonide (fluocinolide, fluocinolone acetonide acetate) Procinonide (fluocinolone acetonide propionate) Formocortal Halcinonide Itrocinonide Rofleponide Rofleponide palmitate Tralonide Triamcinolone acetonide Flupamesone (triamcinolone acetonide metembonate) Triamcinolone acetonide esters Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB) Triclonide Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol Cortivazol Domoprednate Naflocort Nicocortonide Nicocortonide acetate Nivacortol (nivazol) Oxisopred RU-26988 RU-28362 Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate 17α-Hydroxyprogesterone Bromoketoprogesterone Chlormadinone acetate Cyproterone Cyproterone acetate Danazol Delmadinone acetate Desogestrel DU-41165 Etonogestrel Flugestone Flugestone acetate (flurogestone acetate) Fluoromedroxyprogesterone acetate Fluoxymesterone Gestodene Medrogestone Medroxyprogesterone acetate Megestrol acetate Metribolone Norgestomet Osaterone acetate Progesterone Promegestone RU-2309 Quingestrone Segesterone acetate (nestorone) Tetrahydrogestrinone Nonsteroidal glucocorticoids: AZD-5423 GSK-9027
Mixed (SEGRMsTooltip Selective glucocorticoid receptor agonists)	Dagrocorat Fosdagrocorat Mapracorat
Antagonists	7α-Hydroxy-DHEA 17α-Methylprogesterone Aglepristone Asoprisnil Asoprisnil ecamate C108297 C113176 CORT-108297 Cyproterone acetate Dazucorilant Exicorilant (CORT-125281) Guggulsterone Ketoconazole Lilopristone LLY-2707 Metapristone (RU-42633) Miconazole Mifepristone (RU-486) Miricorilant (CORT-118335) Onapristone ORG-34116 ORG-34517 (SCH-900636) ORG-34850 Pregnenolone 16α-carbonitrile Relacorilant (CORT-125134) RTI 3021–012 RTI 3021–022 Telapristone Tibolone Toripristone Ulipristal acetate Zavacorilant
Others	Antisense oligonucleotides: IONIS-GCCR_Rx (ISIS-426115)

See also: Receptor/signaling modulators; Glucocorticoids and antiglucocorticoids; Mineralocorticoid receptor modulators; List of corticosteroids

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