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Dexamethasone isonicotinate

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Chemical compound Pharmaceutical compound
Dexamethasone isonicotinate
Skeletal formula of dexamethasone isonicotinate
Ball-and-stick model of the dexamethasone isonicotinate molecule
Clinical data
Trade namesAuxiloson, Auxilson, Auxilsone, Voren
Other namesDexamethasone 21-isonicotinate; Dexamethasone 21-(4-Pyridinecarboxylate); HE-111; 9α-Fluoro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl isonicotinate; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(4-pyridinecarboxylate)
Identifiers
IUPAC name
  • 2-phenanthren-1-yl]-2-oxoethyl pyridine-4-carboxylate
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.017.152 Edit this at Wikidata
Chemical and physical data
FormulaC28H32FNO6
Molar mass497.563 g·mol
3D model (JSmol)
SMILES
  • C1C23CCC4=CC(=O)C=C4(3((C2(1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C
InChI
  • InChI=1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1
  • Key:BQTXJHAJMDGOFI-NJLPOHDGSA-N

Dexamethasone isonicotinate is an anti-inflammatory, anti-allergic glucocorticoid that can be administered orally, by inhalation, locally, and parenterally. It may cause salt and water retention.

References

  1. Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 367–. ISBN 978-1-4757-2085-3.
  2. Swiss Pharmaceutical Society (2000). Swiss Pharmaceutical Society (ed.). Index Nominum 2000: International Drug Directory. Taylor & Francis. pp. 310–. ISBN 978-3-88763-075-1.


Glucocorticoids and antiglucocorticoids (D07, H02)
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Glucocorticoid receptor modulators
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List of corticosteroids
Glucocorticoid receptor modulators
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
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See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids


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