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Methylprednisolone succinate

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Chemical compound

Pharmaceutical compound
Methylprednisolone succinate
Clinical data
Trade namesSolu-Medrol, Solu-Medrone, Urbason, others
Other namesMethylprednisolone hemisuccinate; 6α-Methylprednisolone 21-hemisuccinate
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous injection
Drug classCorticosteroid; Glucocorticoid
ATC code
Legal status
Legal status
Identifiers
IUPAC name
  • 4-phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.017.416 Edit this at Wikidata
Chemical and physical data
FormulaC26H34O8
Molar mass474.550 g·mol
3D model (JSmol)
SMILES
  • C1C23CC(3(C(24(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
InChI
  • InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1
  • Key:IMBXEJJVJRTNOW-XYMSELFBSA-N

Methylprednisolone succinate, sold under the brand name Solu-Medrol among others, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically the C21 succinate ester of methylprednisolone—which is used by intravenous administration. Methylprednisolone succinate is provided as two different salts when used as a pharmaceutical drug: a sodium salt (methylprednisolone sodium succinate; brand name Solu-Medrol, others) and a hydrogen salt (methylprednisolone hemisuccinate or methylprednisolone hydrogen succinate; brand name Urbason).

Methylprednisolone succinate was approved for medical use in the United States in 1959.

References

  1. "Solu-Medrol Product information". Health Canada. 3 February 2009. Retrieved 19 April 2024.
  2. ^ "Solu-Medrol- methylprednisolone sodium succinate injection, powder, for solution". DailyMed. 17 December 2021. Retrieved 23 December 2023.
  3. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3.
  4. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1.
Glucocorticoids and antiglucocorticoids (D07, H02)
Glucocorticoids
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Glucocorticoid receptor modulators
Mineralocorticoids and antimineralocorticoids
List of corticosteroids
Glucocorticoid receptor modulators
GRTooltip Glucocorticoid receptor
Agonists
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(SEGRMsTooltip Selective glucocorticoid receptor agonists)
Antagonists
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See also
Receptor/signaling modulators
Glucocorticoids and antiglucocorticoids
Mineralocorticoid receptor modulators
List of corticosteroids
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