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Fluocinonide

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Pharmaceutical compound
Fluocinonide
Clinical data
Trade namesFluonex, Lidex, others
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa601054
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: WARNINGRx-only
Pharmacokinetic data
MetabolismLiver
Identifiers
IUPAC name
  • 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.005.998 Edit this at Wikidata
Chemical and physical data
FormulaC26H32F2O7
Molar mass494.532 g·mol
3D model (JSmol)
SMILES
  • O=C(OCC(=O)45OC(O5C24(C(O)3(F)/1(/C=C\C(=O)\C=C\1(F)C23)C)C)(C)C)C
InChI
  • InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
  • Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N
  (verify)

Fluocinonide is a potent glucocorticoid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.

A common potential adverse effect is skin atrophy (thinning of the skin).

In 2022, it was the 266th most commonly prescribed medication in the United States, with more than 1 million prescriptions.

Veterinary uses

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs. Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.

References

  1. "Fluocinonide Topical". MedlinePlus Drug Information. U.S. National Library of Medicine.
  2. "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  3. ^ "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 16 November 2022.
  4. Jablonska S, Groniowska M, Dabroswki J (February 1979). "Comparative evaluation of skin atrophy in man induced by topical corticoids". The British Journal of Dermatology. 100 (2): 193–206. doi:10.1111/j.1365-2133.1979.tb05561.x. PMID 154921. S2CID 30656827.
  5. "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  6. "Fluocinonide Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
  7. Dog Allergies. Squidoo (Report).
  8. Zenoble RD, Kemppainen RJ (September 1987). "Adrenocortical suppression by topically applied corticosteroids in healthy dogs". Journal of the American Veterinary Medical Association. 191 (6): 685–688. PMID 2824410.
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